Literature DB >> 26292759

Ube2s regulates Sox2 stability and mouse ES cell maintenance.

J Wang1, Y Zhang1, J Hou1, X Qian1, H Zhang1, Z Zhang1, M Li1, R Wang1, K Liao1, Y Wang1, Z Li1, D Zhong1, P Wan1, L Dong2, F Liu3, X Wang2, Y Wan3, W Xiao1, W W Zhang1.   

Abstract

Sox2 has a critical role in embryonic stem (ES) cell maintenance and differentiation. Interestingly, its activity is highly dosage-dependent. Although transcriptional regulation of Sox2 has been extensively studied, the mechanisms orchestrating its degradation remain unclear. In this study, we identified ubiquitin-conjugating enzyme E2S (Ube2s) as a novel effector for Sox2 protein degradation. Ube2s mediates K11-linked polyubiquitin chain formation at the Sox2-K123 residue, thus marking it for proteasome-mediated degradation. Besides its role in fine-tuning the precise level of Sox2, Ube2s reinforces the self-renewing and pluripotent state of ES cells. Importantly, it also represses Sox2-mediated ES cell differentiation toward the neural ectodermal lineage.

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Year:  2015        PMID： 26292759      PMCID： PMC5072435          DOI： 10.1038/cdd.2015.106

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  60 in total

1.  Core transcriptional regulatory circuitry in human embryonic stem cells.

Authors:  Laurie A Boyer; Tong Ihn Lee; Megan F Cole; Sarah E Johnstone; Stuart S Levine; Jacob P Zucker; Matthew G Guenther; Roshan M Kumar; Heather L Murray; Richard G Jenner; David K Gifford; Douglas A Melton; Rudolf Jaenisch; Richard A Young
Journal:  Cell       Date:  2005-09-23       Impact factor: 41.582

2.  Characterization of polyubiquitin chain structure by middle-down mass spectrometry.

Authors:  Ping Xu; Junmin Peng
Journal:  Anal Chem       Date:  2008-03-20       Impact factor: 6.986

3.  Pluripotency re-centered around Esrrb.

Authors:  Bernadett Papp; Kathrin Plath
Journal:  EMBO J       Date:  2012-10-12       Impact factor: 11.598

Review 4.  Embryo-derived stem cells: of mice and men.

Authors:  A G Smith
Journal:  Annu Rev Cell Dev Biol       Date:  2001       Impact factor: 13.827

5.  UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

Authors:  Tao Wu; Yifat Merbl; Ying Huo; Jennifer L Gallop; Amit Tzur; Marc W Kirschner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-06       Impact factor: 11.205

6.  Identification of a physiological E2 module for the human anaphase-promoting complex.

Authors:  Adam Williamson; Katherine E Wickliffe; Barbara G Mellone; Ling Song; Gary H Karpen; Michael Rape
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-12       Impact factor: 11.205

Review 7.  Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors.

Authors:  Véronique Lefebvre; Bogdan Dumitriu; Alfredo Penzo-Méndez; Yu Han; Bhattaram Pallavi
Journal:  Int J Biochem Cell Biol       Date:  2007-06-06       Impact factor: 5.085

8.  The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.

Authors:  Yosef Buganim; Styliani Markoulaki; Niek van Wietmarschen; Heather Hoke; Tao Wu; Kibibi Ganz; Batool Akhtar-Zaidi; Yupeng He; Brian J Abraham; David Porubsky; Elisabeth Kulenkampff; Dina A Faddah; Linyu Shi; Qing Gao; Sovan Sarkar; Malkiel Cohen; Johanna Goldmann; Joseph R Nery; Matthew D Schultz; Joseph R Ecker; Andrew Xiao; Richard A Young; Peter M Lansdorp; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2014-09-04       Impact factor: 24.633

9.  An extended transcriptional network for pluripotency of embryonic stem cells.

Authors:  Jonghwan Kim; Jianlin Chu; Xiaohua Shen; Jianlong Wang; Stuart H Orkin
Journal:  Cell       Date:  2008-03-21       Impact factor: 41.582

10.  Multipotent cell lineages in early mouse development depend on SOX2 function.

Authors:  Ariel A Avilion; Silvia K Nicolis; Larysa H Pevny; Lidia Perez; Nigel Vivian; Robin Lovell-Badge
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361
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  24 in total

1.  RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis.

Authors:  Sajad Mir; Weikang Cai; Douglas A Andres
Journal:  J Biol Chem       Date:  2016-12-22       Impact factor: 5.157

Review 2.  The role of ubiquitination in tumorigenesis and targeted drug discovery.

Authors:  Lu Deng; Tong Meng; Lei Chen; Wenyi Wei; Ping Wang
Journal:  Signal Transduct Target Ther       Date:  2020-02-29

3.  Pluripotency gene network dynamics: System views from parametric analysis.

Authors:  Ilya R Akberdin; Nadezda A Omelyanchuk; Stanislav I Fadeev; Natalya E Leskova; Evgeniya A Oschepkova; Fedor V Kazantsev; Yury G Matushkin; Dmitry A Afonnikov; Nikolay A Kolchanov
Journal:  PLoS One       Date:  2018-03-29       Impact factor: 3.240

4.  The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells.

Authors:  Yuan Yin; Chuan-Ming Xie; Hua Li; Mingjia Tan; Guoan Chen; Rachel Schiff; Xiufang Xiong; Yi Sun
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-23       Impact factor: 11.205

5.  FOXOs modulate proteasome activity in human-induced pluripotent stem cells of Huntington's disease and their derived neural cells.

Authors:  Yanying Liu; Fangfang Qiao; Patricia C Leiferman; Alan Ross; Evelyn H Schlenker; Hongmin Wang
Journal:  Hum Mol Genet       Date:  2017-11-15       Impact factor: 6.150

6.  The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein.

Authors:  Xiaohui Hua; Maowen Huang; Xu Deng; Jiheng Xu; Yisi Luo; Qipeng Xie; Jiawei Xu; Zhongxian Tian; Jingxia Li; Junlan Zhu; Chao Huang; Qin-Shi Zhao; Haishan Huang; Chuanshu Huang
Journal:  Cell Death Differ       Date:  2019-06-26       Impact factor: 15.828

7.  Comprehensive Transcriptome Analysis of mRNA Expression Patterns of Early Embryo Development in Goat under Hypoxic and Normoxic Conditions.

Authors:  Yongjie Wan; Dongxu Li; Mingtian Deng; Zifei Liu; Liang Liu; Feng Wang
Journal:  Biology (Basel)       Date:  2021-04-28

8.  BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding.

Authors:  Mingzhu Wang; Kun Zhao; Meng Liu; Mengting Wang; Zhibin Qiao; Shanru Yi; Yonghua Jiang; Xiaochen Kou; Yanhong Zhao; Jiqing Yin; Tianming Li; Hong Wang; Cizhong Jiang; Shaorong Gao; Jiayu Chen
Journal:  Protein Cell       Date:  2022-08       Impact factor: 15.328

9.  Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.

Authors:  Hang T Pham; Tram T T Nguyen; Lap P Nguyen; Sang-Seop Han; Yun-Sook Lim; Soon B Hwang
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

10.  Molecular and functional interactions between AKT and SOX2 in breast carcinoma.

Authors:  Thorsten Schaefer; Hui Wang; Perihan Mir; Martina Konantz; Tamara C Pereboom; Anna M Paczulla; Britta Merz; Tanja Fehm; Sven Perner; Oliver C Rothfuss; Lothar Kanz; Klaus Schulze-Osthoff; Claudia Lengerke
Journal:  Oncotarget       Date:  2015-12-22
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