Damped oscillations in a multiple delayed feedback NF-κB signaling module.

The NF-[Formula: see text]B signaling system regulates a number of cellular processes. Recent studies with simplified models found a damped function of the dual delayed feedback NF-κB signaling module. We use a computational model to investigate how multiple delayed feedback aids achieving damping oscillation in the system and how internal noise can influence the damping function. A curve-fitting method (CFM) is introduced to quantify the damped oscillation. Our results show that (1) the structure of multiple delayed feedback, containing double or triple significantly delayed feedback, determines achieving damped oscillation. (2) Internal noise could aid the system to achieve damped oscillation under almost all circumstances.