Rong Wang1,2, Yu Wang3,4, Dazhou Li1, Li Yu5, Gang Liu1, Jun Ma4, Wen Wang6,7. 1. Department of Gastroenterology, Fuzhou General Hospital, No.156 Xi'erhuan North Rd, Fuzhou, 350025, Fujian, China. 2. Department of Gastroenterology, Dongfang Hospital, Xiamen University, Fuzhou, 350025, Fujian, China. 3. Department of General Surgery, Fuzhou General Hospital, No.156 Xi'erhuan North Rd, Fuzhou, 350025, Fujian, China. 4. Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, Fujian, China. 5. Department of Gastroenterology, Fuzhou General Hospital, Fujian Medical University, No.156 Xi'erhuan North Rd, Fuzhou, 350025, Fujian, China. 6. Department of Gastroenterology, Fuzhou General Hospital, No.156 Xi'erhuan North Rd, Fuzhou, 350025, Fujian, China. wangw68@medmail.com.cn. 7. Department of Gastroenterology, Dongfang Hospital, Xiamen University, Fuzhou, 350025, Fujian, China. wangw68@medmail.com.cn.
Abstract
BACKGROUND:Endoscopic surgery has been a novel treatment for colon polyps or even early colorectal cancer. However, the exact re-inspection after colonic polypectomy to detect the scar from polyp removal was difficult to be performed. In our previous study, colon cancer tattooed with carbon nanoparticles was easily found during surgery. We speculated that carbon nanoparticles could be used in exact re-inspection after colonic polypectomy. OBJECTIVE: To evaluate the efficiency of carbon nanoparticles for re-inspection after colonic polypectomy. METHODS:Twenty-four patients with precancerous lesion or early colorectal cancer that underwent colonoscopic polypectomy between October 2012 and December 2013 were enrolled in the study. Participants were divided into two groups. Group A patients were injected with carbon nanoparticles beneath the lesion sites 3 cm. Group B patients were not treated with nanoparticles. All patients underwent quarterly colonoscopies. Once the colonoscope was withdrawn from the site last time record, the time spent searching for lesions was recorded. RESULTS: There were no significant differences between general conditions or lesion pathology between the groups. The time spent searching for lesions in Group B was much longer than that in Group A (13.67 ± 8.07 vs. 1.21 ± 0.39 min, P < 0.001). Carbon nanoparticles marked lesions for 12 months in some patients, and no adverse reactions were reported. LIMITATIONS: It was a small sample study. CONCLUSIONS: Tattooing lesions using carbon nanoparticles suspensions is safe. The durability of dye enables lesions to be re-checked by colonoscopy or laparoscopy for up to 1 year.
RCT Entities:
BACKGROUND: Endoscopic surgery has been a novel treatment for colon polyps or even early colorectal cancer. However, the exact re-inspection after colonic polypectomy to detect the scar from polyp removal was difficult to be performed. In our previous study, colon cancer tattooed with carbon nanoparticles was easily found during surgery. We speculated that carbon nanoparticles could be used in exact re-inspection after colonic polypectomy. OBJECTIVE: To evaluate the efficiency of carbon nanoparticles for re-inspection after colonic polypectomy. METHODS: Twenty-four patients with precancerous lesion or early colorectal cancer that underwent colonoscopic polypectomy between October 2012 and December 2013 were enrolled in the study. Participants were divided into two groups. Group A patients were injected with carbon nanoparticles beneath the lesion sites 3 cm. Group B patients were not treated with nanoparticles. All patients underwent quarterly colonoscopies. Once the colonoscope was withdrawn from the site last time record, the time spent searching for lesions was recorded. RESULTS: There were no significant differences between general conditions or lesion pathology between the groups. The time spent searching for lesions in Group B was much longer than that in Group A (13.67 ± 8.07 vs. 1.21 ± 0.39 min, P < 0.001). Carbon nanoparticles marked lesions for 12 months in some patients, and no adverse reactions were reported. LIMITATIONS: It was a small sample study. CONCLUSIONS: Tattooing lesions using carbon nanoparticles suspensions is safe. The durability of dye enables lesions to be re-checked by colonoscopy or laparoscopy for up to 1 year.
Entities:
Keywords:
Carbon nanoparticles; Colonoscopic polypectomy; Early colorectal cancer; Tattoo
Authors: Michal F Kaminski; Siwan Thomas-Gibson; Marek Bugajski; Michael Bretthauer; Colin J Rees; Evelien Dekker; Geir Hoff; Rodrigo Jover; Stepan Suchanek; Monika Ferlitsch; John Anderson; Thomas Roesch; Rolf Hultcranz; Istvan Racz; Ernst J Kuipers; Kjetil Garborg; James E East; Maciej Rupinski; Birgitte Seip; Cathy Bennett; Carlo Senore; Silvia Minozzi; Raf Bisschops; Dirk Domagk; Roland Valori; Cristiano Spada; Cesare Hassan; Mario Dinis-Ribeiro; Matthew D Rutter Journal: United European Gastroenterol J Date: 2017-03-16 Impact factor: 4.623