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Literature DB >> 26285147

Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway.

Abstract

Two 2″-isopropenyl dihydrofuran isoflavonoids (1 and 3), one 2″-isopropenyl dihydrofuran chromone (2), as well as 13 known compounds were isolated from the herbs of Crotalaria albida. Their structures and relative configurations were elucidated via NMR and HRESIMS analyses. The 2″ S absolute configuration of 1 and 2 were deduced by comparing their NOESY spectra with that of 3, which was determined via single crystal X-ray diffraction (CuKα). The 3R absolute configuration of 1 was determined by CD. Compounds 1, 2, and 3 inhibit the adipocyte differentiation and lipid accumulation of 3T3-L1 through down-regulation of PPAR-γ activity.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Flavonoids
PPAR gamma

Year: 2015 PMID： 26285147 PMCID： PMC4540591 DOI： 10.1371/journal.pone.0135893

Source DB: PubMed Journal: PLoS One ISSN： 1932-6203 Impact factor: 3.240

23 in total

Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway.

1. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.

2. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.

3. Flavonoid constituents from the roots of Acanthopanax brachypus.

4. Chemical composition and biological activity of a new type of Brazilian propolis: red propolis.

5. Antiplasmodial isoflavanones from the roots of Sophora mollis.

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9. Genistein suppresses mammary cancer in rats.

10. Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice.

1. Synthesis and anti-obesity effects in vivo of Crotadihydrofuran C as a novel PPARγ antagonist from Crotalaria albida.

Review 2. Nutrigenomic Functions of PPARs in Obesogenic Environments.

3. The Effects of Gelatinized Wheat Starch and High Salt Diet on Gut Microbiota and Metabolic Disorder.

4. Competitive CatSper Activators of Progesterone from Rhynchosia volubilis.