PURPOSE: We compared longitudinal changes in functional and structural measures in eyes with glaucomatous optic neuropathy. METHODS: Circumpapillary retinal nerve fiber layer thickness (cpRNFL) and macular ganglion cell complex thickness (mGCC) were measured using spectral-domain optical coherence tomography (SD-OCT; RTVue). The Spectralis HRA+OCT instrument also was used to measure cpRNFL, and Heidelberg retina tomography II (HRT) and standard automated perimetry (SAP) were performed. Assessments were performed every 3 months over several years. Linear mixed modeling was used to evaluate the rate of change in each measure. RESULTS: Totals of 1406 RTVue, 1366 Spectralis, 1245 HRT, and 1392 SAP measurements were analyzed. Average baseline SAP mean deviation (MD) was -6.24 ± 5.46 dB. Linear mixed modeling revealed that SAP MD changed by -0.23 dB/y (95% confidence interval [CI], -0.34 to -0.12 dB/y). Significant negative trends also were detected in cpRNFL (RTVue, -0.41 μm/y [95% CI, -0.67 to -0.16 μm/y]; Spectralis, -1.36 μm/y [95% CI, -1.65 to -1.07 μm/y]; and mGCC (RTVue, -0.47 μm/y [95% CI, -0.64 to -0.30 μm/y]). Disc rim area remained constant over time (HRT, -0.01 mm2/y [95% CI, -0.03 to 0.01 mm2/y]). The SAP MD, RTVue mGCC, and Spectralis cpRNFL showed the fastest changes in the inferior retina (superior visual field), while RTVue cpRNFL changed the fastest in the superior retina. CONCLUSIONS: Functional (SAP) and structural (SD-OCT) testing can detect longitudinal changes of glaucomatous optic neuropathy, but in different ways.
PURPOSE: We compared longitudinal changes in functional and structural measures in eyes with glaucomatous optic neuropathy. METHODS: Circumpapillary retinal nerve fiber layer thickness (cpRNFL) and macular ganglion cell complex thickness (mGCC) were measured using spectral-domain optical coherence tomography (SD-OCT; RTVue). The Spectralis HRA+OCT instrument also was used to measure cpRNFL, and Heidelberg retina tomography II (HRT) and standard automated perimetry (SAP) were performed. Assessments were performed every 3 months over several years. Linear mixed modeling was used to evaluate the rate of change in each measure. RESULTS: Totals of 1406 RTVue, 1366 Spectralis, 1245 HRT, and 1392 SAP measurements were analyzed. Average baseline SAP mean deviation (MD) was -6.24 ± 5.46 dB. Linear mixed modeling revealed that SAP MD changed by -0.23 dB/y (95% confidence interval [CI], -0.34 to -0.12 dB/y). Significant negative trends also were detected in cpRNFL (RTVue, -0.41 μm/y [95% CI, -0.67 to -0.16 μm/y]; Spectralis, -1.36 μm/y [95% CI, -1.65 to -1.07 μm/y]; and mGCC (RTVue, -0.47 μm/y [95% CI, -0.64 to -0.30 μm/y]). Disc rim area remained constant over time (HRT, -0.01 mm2/y [95% CI, -0.03 to 0.01 mm2/y]). The SAP MD, RTVue mGCC, and Spectralis cpRNFL showed the fastest changes in the inferior retina (superior visual field), while RTVue cpRNFL changed the fastest in the superior retina. CONCLUSIONS: Functional (SAP) and structural (SD-OCT) testing can detect longitudinal changes of glaucomatous optic neuropathy, but in different ways.
Authors: Abinaya Thenappan; Carlos Gustavo De Moraes; Diane L Wang; Daiyan Xin; Ravivarn Jarukasetphon; Robert Ritch; Donald C Hood Journal: J Glaucoma Date: 2017-05 Impact factor: 2.503
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Authors: Vahid Mohammadzadeh; Alessandro Rabiolo; Qiang Fu; Esteban Morales; Anne L Coleman; Simon K Law; Joseph Caprioli; Kouros Nouri-Mahdavi Journal: Ophthalmology Date: 2020-01-22 Impact factor: 12.079