Chiara Biagetti1, Rosaria Gesuita2, Simona Gatti3, Carlo Catassi4. 1. Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy. Electronic address: chiara.biagetti@ospedaliriuniti.marche.it. 2. Centre of Epidemiology, Biostatistics and Medical Information Technology, Università Politecnica delle Marche, Ancona, Italy. Electronic address: r.gesuita@univpm.it. 3. Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy. Electronic address: simona.gatti@hotmail.it. 4. Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy. Electronic address: c.catassi@univpm.it.
Abstract
BACKGROUND: Few studies investigated factors influencing the quality of life of children with celiac disease on a gluten-free diet. AIMS: To investigate the impact of the gluten-free diet on the psycho-physical well-being of celiac children. METHODS: In this cross-sectional study, we interviewed 76 celiac and 143 non-celiac children (2-18 years) by using a non-disease specific questionnaire (Pediatric Quality of Life Inventory Test) and we explored the impact of the diet on social life with an open-ended questionnaire. Scores were compared by Wilcoxon rank-sum test. A quantile regression analysis was used to evaluate the impact of celiac disease on score distribution. RESULTS: No significant differences in quality of life were found between the two groups (total score: 84.1 (81.1-87.2) vs 81.5 (79.7-83.4), median (95% CI), patients and controls respectively, p=0.4). Treatment positively affected quality of life in children that showed "intermediate" scores in the Pediatric Quality of Life Inventory Test. Lowest scores were observed in children reporting a higher number of diet difficulties or co-morbidities. CONCLUSIONS: Although celiac patients showed an overall good quality of life in comparison with a control group, by using appropriate analytical methods we elicited specific factors contributing to a lower quality of life in patients, such as co-morbidities and difficulties with the diet.
BACKGROUND: Few studies investigated factors influencing the quality of life of children with celiac disease on a gluten-free diet. AIMS: To investigate the impact of the gluten-free diet on the psycho-physical well-being of celiac children. METHODS: In this cross-sectional study, we interviewed 76 celiac and 143 non-celiac children (2-18 years) by using a non-disease specific questionnaire (Pediatric Quality of Life Inventory Test) and we explored the impact of the diet on social life with an open-ended questionnaire. Scores were compared by Wilcoxon rank-sum test. A quantile regression analysis was used to evaluate the impact of celiac disease on score distribution. RESULTS: No significant differences in quality of life were found between the two groups (total score: 84.1 (81.1-87.2) vs 81.5 (79.7-83.4), median (95% CI), patients and controls respectively, p=0.4). Treatment positively affected quality of life in children that showed "intermediate" scores in the Pediatric Quality of Life Inventory Test. Lowest scores were observed in children reporting a higher number of diet difficulties or co-morbidities. CONCLUSIONS: Although celiac patients showed an overall good quality of life in comparison with a control group, by using appropriate analytical methods we elicited specific factors contributing to a lower quality of life in patients, such as co-morbidities and difficulties with the diet.
Authors: J W Cadenhead; R L Wolf; B Lebwohl; A R Lee; P Zybert; N R Reilly; J Schebendach; R Satherley; P H R Green Journal: J Hum Nutr Diet Date: 2019-03-05 Impact factor: 3.089
Authors: Jonas F Ludvigsson; Carolina Ciacci; Peter Hr Green; Katri Kaukinen; Ilma R Korponay-Szabo; Kalle Kurppa; Joseph A Murray; Knut Erik Aslaksen Lundin; Markku J Maki; Alina Popp; Norelle R Reilly; Alfonso Rodriguez-Herrera; David S Sanders; Detlef Schuppan; Sarah Sleet; Juha Taavela; Kristin Voorhees; Marjorie M Walker; Daniel A Leffler Journal: Gut Date: 2018-02-13 Impact factor: 23.059