Literature DB >> 26278990

[Organ preserving strategies for rectal cancer treatment].

V Vendrely1, Q Denost2, F Amestoy3, B Célérier2, D Smith4, A Rullier5, É Rullier2.   

Abstract

For rectal cancers, the current standard of care consists of chemoradiation followed by radical surgery with total mesorectal excision. Oncologic results are good, especially regarding local recurrence rates, but at the cost of high morbidity rates and poor anorectal, urinary and sexual function results. Since chemoradiation yields 15 to 25% pathological complete response, the role of radical surgery is questioned for patients presenting with good response after chemoradiation and two organ preservation strategies have been offered: watch and wait strategy and local excision strategy. The aim of this review is to give the results of organ preservation after chemoradiotherapy series and to highlight different questions regarding initial patient's selection, complete clinical response definition, risk of mesorectal nodal involvement, follow-up modalities as well as oncologic and functional results.
Copyright © 2015 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

Entities:  

Keywords:  Cancer du rectum; Chimioradiothérapie; Exérèse locale; Local excision; Organ preservation; Préservation d’organe; Rectal cancer; Tumour response; Watch and wait

Mesh:

Year:  2015        PMID: 26278990     DOI: 10.1016/j.canrad.2015.05.009

Source DB:  PubMed          Journal:  Cancer Radiother        ISSN: 1278-3218            Impact factor:   1.018


  1 in total

1.  Handheld macroscopic Raman spectroscopy imaging instrument for machine-learning-based molecular tissue margins characterization.

Authors:  François Daoust; Tien Nguyen; Patrick Orsini; Jacques Bismuth; Marie-Maude de Denus-Baillargeon; Israel Veilleux; Alexandre Wetter; Philippe Mckoy; Isabelle Dicaire; Maroun Massabki; Kevin Petrecca; Frédéric Leblond
Journal:  J Biomed Opt       Date:  2021-02       Impact factor: 3.170

  1 in total

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