| Literature DB >> 26278990 |
V Vendrely1, Q Denost2, F Amestoy3, B Célérier2, D Smith4, A Rullier5, É Rullier2.
Abstract
For rectal cancers, the current standard of care consists of chemoradiation followed by radical surgery with total mesorectal excision. Oncologic results are good, especially regarding local recurrence rates, but at the cost of high morbidity rates and poor anorectal, urinary and sexual function results. Since chemoradiation yields 15 to 25% pathological complete response, the role of radical surgery is questioned for patients presenting with good response after chemoradiation and two organ preservation strategies have been offered: watch and wait strategy and local excision strategy. The aim of this review is to give the results of organ preservation after chemoradiotherapy series and to highlight different questions regarding initial patient's selection, complete clinical response definition, risk of mesorectal nodal involvement, follow-up modalities as well as oncologic and functional results.Entities:
Keywords: Cancer du rectum; Chimioradiothérapie; Exérèse locale; Local excision; Organ preservation; Préservation d’organe; Rectal cancer; Tumour response; Watch and wait
Mesh:
Year: 2015 PMID: 26278990 DOI: 10.1016/j.canrad.2015.05.009
Source DB: PubMed Journal: Cancer Radiother ISSN: 1278-3218 Impact factor: 1.018