| Literature DB >> 26276630 |
Kristian G Andersen1, B Jesse Shapiro2, Christian B Matranga3, Rachel Sealfon4, Aaron E Lin5, Lina M Moses6, Onikepe A Folarin7, Augustine Goba8, Ikponmwonsa Odia9, Philomena E Ehiane9, Mambu Momoh10, Eleina M England3, Sarah Winnicki5, Luis M Branco11, Stephen K Gire5, Eric Phelan3, Ridhi Tariyal3, Ryan Tewhey5, Omowunmi Omoniwa9, Mohammed Fullah10, Richard Fonnie8, Mbalu Fonnie8, Lansana Kanneh8, Simbirie Jalloh8, Michael Gbakie8, Sidiki Saffa8, Kandeh Karbo8, Adrianne D Gladden3, James Qu3, Matthew Stremlau5, Mahan Nekoui5, Hilary K Finucane3, Shervin Tabrizi5, Joseph J Vitti12, Bruce Birren3, Michael Fitzgerald3, Caryn McCowan3, Andrea Ireland3, Aaron M Berlin3, James Bochicchio3, Barbara Tazon-Vega3, Niall J Lennon3, Elizabeth M Ryan3, Zach Bjornson13, Danny A Milner14, Amanda K Lukens14, Nisha Broodie15, Megan Rowland11, Megan Heinrich11, Marjan Akdag11, John S Schieffelin6, Danielle Levy6, Henry Akpan16, Daniel G Bausch6, Kathleen Rubins17, Joseph B McCormick18, Eric S Lander3, Stephan Günther19, Lisa Hensley20, Sylvanus Okogbenin9, Stephen F Schaffner3, Peter O Okokhere9, S Humarr Khan8, Donald S Grant8, George O Akpede9, Danny A Asogun9, Andreas Gnirke3, Joshua Z Levin3, Christian T Happi21, Robert F Garry6, Pardis C Sabeti22.
Abstract
The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.Entities:
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Year: 2015 PMID： 26276630 PMCID： PMC4537774 DOI： 10.1016/j.cell.2015.07.020
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582