Thomas S Postler1, Sankar Ghosh1. 1. Department of Microbiology & Immunology, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA.
Abstract
BACKGROUND: A close connection between inflammation and cancer has now been firmly established. While tumor initiation is typically independent of inflammatory events, immune cells infiltrating the tumor microenvironment secrete inflammatory cytokines that enhance the aberrant growth of tumor cells and thus facilitate tumor progression. Therefore, inflammation and tumor growth are usually interpreted as closely related on a systemic level but as distinct, independently regulated processes at a molecular level. HIGHLIGHT: Recently, we reported that a sub-class of small GTPases, namely κB-Ras1 and κB-Ras2, regulate both inflammation and tumor growth, thereby providing a unique molecular bridge between the two biological processes. CONCLUSION: Here, we briefly summarize the known contact points between inflammation and cancer, including oral cancers, and put into context the identification of κB-Ras proteins as molecular link between two independent pathways important for tumor growth.
BACKGROUND: A close connection between inflammation and cancer has now been firmly established. While tumor initiation is typically independent of inflammatory events, immune cells infiltrating the tumor microenvironment secrete inflammatory cytokines that enhance the aberrant growth of tumor cells and thus facilitate tumor progression. Therefore, inflammation and tumor growth are usually interpreted as closely related on a systemic level but as distinct, independently regulated processes at a molecular level. HIGHLIGHT: Recently, we reported that a sub-class of small GTPases, namely κB-Ras1 and κB-Ras2, regulate both inflammation and tumor growth, thereby providing a unique molecular bridge between the two biological processes. CONCLUSION: Here, we briefly summarize the known contact points between inflammation and cancer, including oral cancers, and put into context the identification of κB-Ras proteins as molecular link between two independent pathways important for tumor growth.
Authors: Ying Pan; Si-Chao Huang; Xia Wang; Wu-Xing Gong; Cui-Wei Liang; Jun-Xiang DU; Dong-Xu Peng; Yun Xie; Li-Ping Zheng; Nan Zhang; Wen Quan Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2018-05-20
Authors: Stephanie Beel; Lina Kolloch; Lisa H Apken; Lara Jürgens; Andrea Bolle; Nadine Sudhof; Sankar Ghosh; Eva Wardelmann; Michael Meisterernst; Konrad Steinestel; Andrea Oeckinghaus Journal: Nat Commun Date: 2020-07-08 Impact factor: 17.694