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Literature DB >> 18219307

Ral GTPases and cancer: linchpin support of the tumorigenic platform.

Abstract

A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18219307 DOI： 10.1038/nrc2296

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

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Cited

120 in total

1. IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.

Authors: Peyman Nakhaei; Qiang Sun; Mayra Solis; Thibault Mesplede; Eric Bonneil; Suzanne Paz; Rongtuan Lin; John Hiscott
Journal: J Virol Date: 2011-11-09 Impact factor: 5.103

2. RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.

Authors: Vincent Neyraud; Vasily N Aushev; Anastassia Hatzoglou; Brigitte Meunier; Ilaria Cascone; Jacques Camonis
Journal: J Biol Chem Date: 2012-06-14 Impact factor: 5.157

Review 3. Inhibition of Ras for cancer treatment: the search continues.

Authors: Antonio T Baines; Dapeng Xu; Channing J Der
Journal: Future Med Chem Date: 2011-10 Impact factor: 3.808

4. RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.

Authors: M Lee Schmidt; Katharine R Hobbing; Howard Donninger; Geoffrey J Clark
Journal: Cancer Res Date: 2018-05-07 Impact factor: 12.701

5. Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.

Authors: Wei Peng; Jiwei Xu; Xiaotao Guan; Yao Sun; Xuejun C Zhang; Xuemei Li; Zihe Rao
Journal: Protein Cell Date: 2011-04-14 Impact factor: 14.870

Review 6. Thinking outside the box about Ras.

Authors: John M Kyriakis
Journal: J Biol Chem Date: 2008-12-17 Impact factor: 5.157

Ral GTPases and cancer: linchpin support of the tumorigenic platform.

1. IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.

2. RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.

Review 3. Inhibition of Ras for cancer treatment: the search continues.

4. RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.

5. Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.

Review 6. Thinking outside the box about Ras.

7. RalA functions as an indispensable signal mediator for the nutrient-sensing system.

8. SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers.

9. RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.

10. RalA is overactivated in medulloblastoma.