BACKGROUND: Catheter contact force (CF) has a strong correlation with lesion formation during radiofrequency ablation. Delayed-enhancement cardiac magnetic resonance (DE-CMR) provides lesion information in patients with prior atrial fibrillation (AF) ablation. OBJECTIVE: The aim of this study was to determine the CF threshold to create permanent lesions detected by DE-CMR. METHODS: A total of 36 patients referred for AF ablation were included. A CF catheter was used during the ablation procedure, and DE-CMR was performed 3 months after the ablation procedure. Eighteen pulmonary vein (PV) segments were defined, and 3-dimensional (3D) reconstructions of the left atrium (LA) derived from the DE-CMR images were obtained. One observer evaluated the presence of any discontinuity of previous ablation lesions (gap) in the 3D reconstructions of the LA, and another observer (blinded to the gap findings) determined the minimum CF value in each PV segment. RESULTS: The PV segments where a gap was observed had a lower maximal CF value than did the segments without gap in the 3D LA reconstructions (6.7 ± 4.4 g vs 12.2 ± 4.7 g; P < .001). In receiver operating characteristic analysis, a CF threshold of >8 g provided 73% sensitivity and 81% specificity in the prediction of a complete PV lesion (positive predictive value [PPV] 84%). A CF threshold of >12 g had a specificity of 94% and increased the PPV to 91% in creating a complete lesion in the LA wall (area under the curve 0.834). CONCLUSION: A CF threshold of >12 g H5H20 predicts a complete lesion with high specificity and PPV when a dragging ablation strategy is used in AF ablation.
BACKGROUND: Catheter contact force (CF) has a strong correlation with lesion formation during radiofrequency ablation. Delayed-enhancement cardiac magnetic resonance (DE-CMR) provides lesion information in patients with prior atrial fibrillation (AF) ablation. OBJECTIVE: The aim of this study was to determine the CF threshold to create permanent lesions detected by DE-CMR. METHODS: A total of 36 patients referred for AF ablation were included. A CF catheter was used during the ablation procedure, and DE-CMR was performed 3 months after the ablation procedure. Eighteen pulmonary vein (PV) segments were defined, and 3-dimensional (3D) reconstructions of the left atrium (LA) derived from the DE-CMR images were obtained. One observer evaluated the presence of any discontinuity of previous ablation lesions (gap) in the 3D reconstructions of the LA, and another observer (blinded to the gap findings) determined the minimum CF value in each PV segment. RESULTS: The PV segments where a gap was observed had a lower maximal CF value than did the segments without gap in the 3D LA reconstructions (6.7 ± 4.4 g vs 12.2 ± 4.7 g; P < .001). In receiver operating characteristic analysis, a CF threshold of >8 g provided 73% sensitivity and 81% specificity in the prediction of a complete PV lesion (positive predictive value [PPV] 84%). A CF threshold of >12 g had a specificity of 94% and increased the PPV to 91% in creating a complete lesion in the LA wall (area under the curve 0.834). CONCLUSION: A CF threshold of >12 g H5H20 predicts a complete lesion with high specificity and PPV when a dragging ablation strategy is used in AF ablation.
Authors: Stephanie Fichtner; Reza Wakili; Konstantinos Rizas; Johannes Siebermair; Moritz F Sinner; Thomas Wiktor; Korbinian Lackermair; Franziska Schuessler; Lucia Olesch; Susanne Rainer; Stefan Kääb; Adrian Curta; Harald Kramer; Heidi L Estner Journal: Biomed Res Int Date: 2018-09-18 Impact factor: 3.411
Authors: Larissa Fabritz; Eduard Guasch; Charalambos Antoniades; Isabel Bardinet; Gerlinde Benninger; Tim R Betts; Eva Brand; Günter Breithardt; Gabriela Bucklar-Suchankova; A John Camm; David Cartlidge; Barbara Casadei; Winnie W L Chua; Harry J G M Crijns; Jon Deeks; Stéphane Hatem; Françoise Hidden-Lucet; Stefan Kääb; Nikos Maniadakis; Stephan Martin; Lluis Mont; Holger Reinecke; Moritz F Sinner; Ulrich Schotten; Taunton Southwood; Monika Stoll; Panos Vardas; Reza Wakili; Andy West; André Ziegler; Paulus Kirchhof Journal: Nat Rev Cardiol Date: 2015-12-24 Impact factor: 32.419