Young Min Park1, Soo-Geun Wang2, Jin-Choon Lee3, Dong Hoon Shin4, In-Ju Kim5, Seok-Man Son6, Mijin Mun7, Byung-Joo Lee2. 1. Department of Otorhinolaryngology, Pundang Jesaeng Hospital, Deajin Medical Center, Seongnam, Gyeonggi, Korea. 2. Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea. 3. Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Yangsan, Kyeongnam, Korea. 4. Department of Pathology, Pusan National University School of Medicine and Biomedical Research Institute, Yangsan, Kyeongnam, Korea. 5. Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea. 6. Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Yangsan, Kyeongnam, Korea. 7. Department of Otorhinolaryngology-Head and Neck Surgery, Busan St. Marry's Medical Center, Busan, Korea.
Abstract
BACKGROUND: The purpose of this study was to present our focus on the lymph node status in the central compartment and evaluate the relevant factors and disease recurrence. METHODS: Between January 2004 and December 2009, 1040 patients were diagnosed with papillary thyroid carcinoma (PTC) and underwent surgery. RESULTS: The number of metastatic lymph nodes was a significant predictor for recurrence conferring a hazard ratio of 1.36 (confidence interval = 1.103-1.680; p = .004). The receiver operating characteristic (ROC) curve was calculated to determine the cutoff number of lymph nodes that predicted recurrence with the highest sensitivity and specificity (area under the ROC curve, 0.794; SE, 0.077; p = .001). The sensitivity/specificity of >3 metastatic lymph nodes for predicting recurrence was 63.6%/77.0%, respectively. CONCLUSION: The number of metastatic lymph nodes in the central compartment was a statistical significant predictive factor associated with disease recurrence. Further study is required to confirm the relationship between the number of lymph nodes and disease recurrence.
BACKGROUND: The purpose of this study was to present our focus on the lymph node status in the central compartment and evaluate the relevant factors and disease recurrence. METHODS: Between January 2004 and December 2009, 1040 patients were diagnosed with papillary thyroid carcinoma (PTC) and underwent surgery. RESULTS: The number of metastatic lymph nodes was a significant predictor for recurrence conferring a hazard ratio of 1.36 (confidence interval = 1.103-1.680; p = .004). The receiver operating characteristic (ROC) curve was calculated to determine the cutoff number of lymph nodes that predicted recurrence with the highest sensitivity and specificity (area under the ROC curve, 0.794; SE, 0.077; p = .001). The sensitivity/specificity of >3 metastatic lymph nodes for predicting recurrence was 63.6%/77.0%, respectively. CONCLUSION: The number of metastatic lymph nodes in the central compartment was a statistical significant predictive factor associated with disease recurrence. Further study is required to confirm the relationship between the number of lymph nodes and disease recurrence.
Authors: Yun-Sung Lim; Yoon Se Lee; Jin-Choon Lee; Seok-Man Son; Dong-Hoon Shin; Sang Soo Kim; In-Ju Kim; Byung-Joo Lee Journal: In Vivo Date: 2021 May-Jun Impact factor: 2.406
Authors: Sandeep Kumar Parvathareddy; Abdul K Siraj; Padmanaban Annaiyappanaidu; Nabil Siraj; Saif S Al-Sobhi; Fouad Al-Dayel; Khawla S Al-Kuraya Journal: J Clin Med Date: 2022-08-08 Impact factor: 4.964