Abhishek Shastri1, Santosh Bangar2, John Holmes2,3. 1. Dorset HealthCare University NHS Foundation Trust, Poole, UK. 2. Leeds and York Partnership NHS Foundation Trust, Leeds, UK. 3. Leeds Institute of Medical Education, School of Medicine, University of Leeds, Leeds, UK.
Abstract
OBJECTIVE: Obstructive sleep apnoea is a common sleep disturbance in people of all ages, while dementia is an increasing entity among the ageing population of the world. Recent studies have established a link between sleep apnoea and cognitive decline. This literature review explores this relationship and examines the mechanisms, neurobiology and treatment modalities. DESIGN: The study was conducted with the use of narrative literature overview. RESULTS AND CONCLUSIONS: While there are numerous studies that establish a clear relationship between obstructive sleep apnoea, cognitive decline and dementia, more work is needed in understanding the mechanism and processes involved. A detailed understanding of pathophysiology of sleep and the relationship with cognitive decline will be vital in addressing the possibility of averting a likely reversible cause of dementia or cognitive decline.
OBJECTIVE:Obstructive sleep apnoea is a common sleep disturbance in people of all ages, while dementia is an increasing entity among the ageing population of the world. Recent studies have established a link between sleep apnoea and cognitive decline. This literature review explores this relationship and examines the mechanisms, neurobiology and treatment modalities. DESIGN: The study was conducted with the use of narrative literature overview. RESULTS AND CONCLUSIONS: While there are numerous studies that establish a clear relationship between obstructive sleep apnoea, cognitive decline and dementia, more work is needed in understanding the mechanism and processes involved. A detailed understanding of pathophysiology of sleep and the relationship with cognitive decline will be vital in addressing the possibility of averting a likely reversible cause of dementia or cognitive decline.
Authors: Omonigho M Bubu; Andreia G Andrade; Ogie Q Umasabor-Bubu; Megan M Hogan; Arlener D Turner; Mony J de Leon; Gbenga Ogedegbe; Indu Ayappa; Girardin Jean-Louis G; Melinda L Jackson; Andrew W Varga; Ricardo S Osorio Journal: Sleep Med Rev Date: 2019-12-12 Impact factor: 11.609