Zachary A Marcum1, Subashan Perera2, Anne B Newman3, Joshua M Thorpe4, Galen E Switzer5, Shelly L Gray6, Eleanor M Simonsick7, Ronald I Shorr8, Douglas C Bauer9, Nicholas G Castle10, Stephanie A Studenski11, Joseph T Hanlon12. 1. Department of Medicine (Geriatrics), zmarcum@uw.edu. 2. Department of Medicine (Geriatrics), Department of Biostatistics. 3. Department of Medicine (Geriatrics), Department of Epidemiology, and. 4. Department of Pharmacy and Therapeutics, University of Pittsburgh, Pennsylvania. Center for Health Equity Research, Veterans Affairs Pittsburgh Healthcare System, Pennsylvania. 5. Center for Health Equity Research, Veterans Affairs Pittsburgh Healthcare System, Pennsylvania. Departments of Medicine (General Internal) and Psychiatry, University of Pittsburgh, Pennsylvania. 6. School of Pharmacy, University of Washington, Seattle. 7. Intramural Research Program, National Institute on Aging, Baltimore, Maryland. 8. North Florida/South Georgia Veterans Health System GRECC, Gainesville. 9. Division of General Internal Medicine, University of California at San Francisco. 10. Department of Health Policy and Management, University of Pittsburgh, Pennsylvania. 11. Department of Medicine (Geriatrics). 12. Department of Medicine (Geriatrics), Department of Biostatistics, Department of Epidemiology, and Department of Pharmacy and Therapeutics, University of Pittsburgh, Pennsylvania. Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs Pittsburgh Healthcare System, Pennsylvania.
Abstract
BACKGROUND: Despite wide-spread use of antihypertensives in older adults, the literature is unclear about their association with incident recurrent falls over time. METHODS: Health, Aging and Body Composition study participants (n = 2,948) who were well functioning at baseline (1997) were followed to Year 7 (2004). The main outcome was recurrent falls (≥2) in the ensuing 12 months. Antihypertensive use was examined as: (a) any versus none, (b) long- versus short-term (≥2 vs <2 years), and by (c) summated standardized daily dose (SDD; 1 = maximum recommended daily dose for one antihypertensive), and (d) subclass. RESULTS: Controlling for potential demographic, health status/behavior and access to care confounders, we found no increase in risk of recurrent falls in antihypertensive users compared to nonusers (adjusted odds ratio [AOR] = 1.13; 95% CI = 0.88-1.46), or those taking higher SDDs or for longer durations. Only those using a loop diuretic were found to have a modest increased risk of recurrent falls (AOR = 1.50; 95% CI = 1.11-2.03). CONCLUSIONS: Antihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders. Loop diuretic use may be associated with recurrent falls and needs further study.
BACKGROUND: Despite wide-spread use of antihypertensives in older adults, the literature is unclear about their association with incident recurrent falls over time. METHODS: Health, Aging and Body Composition study participants (n = 2,948) who were well functioning at baseline (1997) were followed to Year 7 (2004). The main outcome was recurrent falls (≥2) in the ensuing 12 months. Antihypertensive use was examined as: (a) any versus none, (b) long- versus short-term (≥2 vs <2 years), and by (c) summated standardized daily dose (SDD; 1 = maximum recommended daily dose for one antihypertensive), and (d) subclass. RESULTS: Controlling for potential demographic, health status/behavior and access to care confounders, we found no increase in risk of recurrent falls in antihypertensive users compared to nonusers (adjusted odds ratio [AOR] = 1.13; 95% CI = 0.88-1.46), or those taking higher SDDs or for longer durations. Only those using a loop diuretic were found to have a modest increased risk of recurrent falls (AOR = 1.50; 95% CI = 1.11-2.03). CONCLUSIONS: Antihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders. Loop diuretic use may be associated with recurrent falls and needs further study.
Authors: Nathalie de Rekeneire; Marjolein Visser; Rita Peila; Michael C Nevitt; Jane A Cauley; Frances A Tylavsky; Eleanor M Simonsick; Tamara B Harris Journal: J Am Geriatr Soc Date: 2003-06 Impact factor: 5.562
Authors: Joseph T Hanlon; Lawrence R Landerman; Gerda G Fillenbaum; Stephanie Studenski Journal: J Gerontol A Biol Sci Med Sci Date: 2002-07 Impact factor: 6.053
Authors: Anne B Newman; Catherine L Haggerty; Stephen B Kritchevsky; Michael C Nevitt; Eleanor M Simonsick Journal: J Gerontol A Biol Sci Med Sci Date: 2003-08 Impact factor: 6.053
Authors: Naoko Sagawa; Zachary A Marcum; Robert M Boudreau; Joseph T Hanlon; Steven M Albert; Celia O'Hare; Suzanne Satterfield; Ann V Schwartz; Aaron I Vinik; Jane A Cauley; Tamara B Harris; Anne B Newman; Elsa S Strotmeyer Journal: Eur J Ageing Date: 2018-01-19
Authors: Eric S Orwoll; Nora F Fino; Thomas M Gill; Jane A Cauley; Elsa S Strotmeyer; Kristine E Ensrud; Deborah M Kado; Elizabeth Barrett-Connor; Douglas C Bauer; Peggy M Cawthon; Jodi Lapidus Journal: J Gerontol A Biol Sci Med Sci Date: 2019-08-16 Impact factor: 6.053
Authors: Tessa van Middelaar; Sophie D Ivens; Petra G van Peet; Rosalinde K E Poortvliet; Edo Richard; A Jeannette Pols; Eric P Moll van Charante Journal: BMJ Open Date: 2018-04-20 Impact factor: 2.692
Authors: Leo D Westbury; Holly E Syddall; Nicholas R Fuggle; Elaine M Dennison; Nicholas C Harvey; Jane A Cauley; Eric J Shiroma; Roger A Fielding; Anne B Newman; Cyrus Cooper Journal: Calcif Tissue Int Date: 2020-11-15 Impact factor: 4.333