Literature DB >> 26265592

Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery.

Jeong Yu Lee1, Dario Carugo1, Calum Crake1, Joshua Owen1, Marie de Saint Victor1, Anjali Seth1, Constantin Coussios1, Eleanor Stride1.   

Abstract

A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.
© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  breast cancer; chemotherapy; microbubbles; nanodroplets; ultrasound

Mesh：

Substances：

Year:  2015        PMID： 26265592     DOI： 10.1002/adma.201502022

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  28 in total

Review 1.  Ultrasound-responsive droplets for therapy: A review.

Authors:  H Lea-Banks; M A O'Reilly; K Hynynen
Journal:  J Control Release       Date:  2018-11-29       Impact factor: 9.776

2.  Noninvasive Ultrasonic Drug Uncaging Maps Whole-Brain Functional Networks.

Authors:  Jeffrey B Wang; Muna Aryal; Qian Zhong; Daivik B Vyas; Raag D Airan
Journal:  Neuron       Date:  2018-11-07       Impact factor: 17.173

Review 3.  Design strategies for physical-stimuli-responsive programmable nanotherapeutics.

Authors:  Fitsum Feleke Sahle; Muhammad Gulfam; Tao L Lowe
Journal:  Drug Discov Today       Date:  2018-04-10       Impact factor: 7.851

4.  Layered acoustofluidic resonators for the simultaneous optical and acoustic characterisation of cavitation dynamics, microstreaming, and biological effects.

Authors:  V Pereno; M Aron; O Vince; C Mannaris; A Seth; M de Saint Victor; G Lajoinie; M Versluis; C Coussios; D Carugo; E Stride
Journal:  Biomicrofluidics       Date:  2018-05-30       Impact factor: 2.800

5.  Acoustic Actuation of Integrin-Bound Microbubbles for Mechanical Phenotyping during Differentiation and Morphogenesis of Human Embryonic Stem Cells.

Authors:  Zhenzhen Fan; Xufeng Xue; Reshani Perera; Sajedeh Nasr Esfahani; Agata A Exner; Jianping Fu; Cheri X Deng
Journal:  Small       Date:  2018-11-14       Impact factor: 13.281

6.  Novel method for the formation of monodisperse superheated perfluorocarbon nanodroplets as activatable ultrasound contrast agents.

Authors:  C de Gracia Lux; A M Vezeridis; J Lux; A M Armstrong; S R Sirsi; K Hoyt; R F Mattrey
Journal:  RSC Adv       Date:  2017-10-16       Impact factor: 3.361

7.  Combined passive acoustic mapping and magnetic resonance thermometry for monitoring phase-shift nanoemulsion enhanced focused ultrasound therapy.

Authors:  Calum Crake; F Can Meral; Mark T Burgess; Iason T Papademetriou; Nathan J McDannold; Tyrone M Porter
Journal:  Phys Med Biol       Date:  2017-07-13       Impact factor: 3.609

8.  Selective intracellular delivery of perfluorocarbon nanodroplets for cytotoxicity threshold reduction on ultrasound-induced vaporization.

Authors:  Ayumu Ishijima; Satoshi Yamaguchi; Takashi Azuma; Etsuko Kobayashi; Yoshikazu Shibasaki; Teruyuki Nagamune; Ichiro Sakuma
Journal:  Cancer Rep (Hoboken)       Date:  2019-02-17

9.  Quantitative Frequency-Domain Passive Cavitation Imaging.

Authors:  Kevin J Haworth; Kenneth B Bader; Kyle T Rich; Christy K Holland; T Douglas Mast
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2016-10-25       Impact factor: 2.725

10.  Multimodal Nanocarrier Probes Reveal Superior Biodistribution Quantification by Isotopic Analysis over Fluorescence.

Authors:  Hongping Deng; Christian J Konopka; Tzu-Wen L Cross; Kelly S Swanson; Lawrence W Dobrucki; Andrew M Smith
Journal:  ACS Nano       Date:  2020-01-07       Impact factor: 15.881
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.