Weijun Ding1, Wei Hu2, Haihua Yang2, Ting Ying2, Ye Tian3. 1. Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China ; Department of Radiotherapy and Oncology, The Affiliated Taizhou Hospital of Wenzhou Medical University Taizhou 317000, China. 2. Department of Radiotherapy and Oncology, The Affiliated Taizhou Hospital of Wenzhou Medical University Taizhou 317000, China. 3. Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
Abstract
OBJECTIVES: Association of MTA2 expression with presence, development, metastasis and prognosis of colorectal cancer (CRC) was investigated. METHODS: 90 CRC-related cases with follow-up information were made into tissue microarrays according to the paired principle of cancer tissues and the adjacent tissues. Subsequently, the expression of MAT2 was detected with immunohistochemical analysis and SPSS software was finally utilized to analyze the relationships between experimental data and clinical indicatives. RESULTS: Expression of MTA2 in CRC tissues were notably higher than their adjacent tissues (P < 0.001) and showed significant positive correlation with tumor grade (r(2) > 0, P < 0.01). Moreover, survival analysis indicated that MTA2 expression in cancer tissues, serving as an independent correlation factor, was significantly correlated with poor prognosis (P = 0.004). CONCLUSIONS: MTA2 is a crucial biomarker that is closely related with prognosis of CRC and also a potential molecular target for evaluating the prognosis and treatment of CRC.
OBJECTIVES: Association of MTA2 expression with presence, development, metastasis and prognosis of colorectal cancer (CRC) was investigated. METHODS: 90 CRC-related cases with follow-up information were made into tissue microarrays according to the paired principle of cancer tissues and the adjacent tissues. Subsequently, the expression of MAT2 was detected with immunohistochemical analysis and SPSS software was finally utilized to analyze the relationships between experimental data and clinical indicatives. RESULTS: Expression of MTA2 in CRC tissues were notably higher than their adjacent tissues (P < 0.001) and showed significant positive correlation with tumor grade (r(2) > 0, P < 0.01). Moreover, survival analysis indicated that MTA2 expression in cancer tissues, serving as an independent correlation factor, was significantly correlated with poor prognosis (P = 0.004). CONCLUSIONS:MTA2 is a crucial biomarker that is closely related with prognosis of CRC and also a potential molecular target for evaluating the prognosis and treatment of CRC.