Tianbo Jin1, Hua Yang1, Jiayi Zhang1, Zulfiya Yunus2, Qiang Sun1, Tingting Geng3, Chao Chen1, Jie Yang4. 1. School of Life Sciences, Northwest University Xi'an, Shaanxi 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi China. 2. College of Life Sciences and Technology, Xinjiang University Urumqi 830046, China. 3. National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi China ; Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine Xi'an 710061, China. 4. Department of Radiotherapy Two, The People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
Abstract
PURPOSE: Genetic polymorphisms in CYP3A4 can change its activity to a certain degree, thus leading to differences among different populations in drug efficacy or adverse drug reactions. METHODS: The study was intended to validate the genetic polymorphisms in CYP3A4 in Uygur Chinese population, we sequenced and screened for genetic variants including 5'UTR, promoters, exons, introns, and 3'UTR region of the whole CYP3A4 gene in 100 unrelated, healthy. RESULTS: Twenty-one genetic polymorphisms in CYP3A4, and nine of them were novel. We detected CYP3A4*8, a putative poor-metabolizer allele, with the frequency of 0.5% in Uygur population. Tfsitescan revealed that the density of transcription factor varied in the different promoter regions, among which some were key regions for transcription factor binding. CONCLUSION: our results provide basic information about CPY3A4 alleles in Uygur and suggest that the enzymatic activities of CPY3A4 may differ among the diverse ethnic populations of China.
PURPOSE: Genetic polymorphisms in CYP3A4 can change its activity to a certain degree, thus leading to differences among different populations in drug efficacy or adverse drug reactions. METHODS: The study was intended to validate the genetic polymorphisms in CYP3A4 in Uygur Chinese population, we sequenced and screened for genetic variants including 5'UTR, promoters, exons, introns, and 3'UTR region of the whole CYP3A4 gene in 100 unrelated, healthy. RESULTS: Twenty-one genetic polymorphisms in CYP3A4, and nine of them were novel. We detected CYP3A4*8, a putative poor-metabolizer allele, with the frequency of 0.5% in Uygur population. Tfsitescan revealed that the density of transcription factor varied in the different promoter regions, among which some were key regions for transcription factor binding. CONCLUSION: our results provide basic information about CPY3A4 alleles in Uygur and suggest that the enzymatic activities of CPY3A4 may differ among the diverse ethnic populations of China.
Authors: Y Ando; T Tateishi; Y Sekido; T Yamamoto; T Satoh; Y Hasegawa; S Kobayashi; Y Katsumata; K Shimokata; H Saito Journal: J Natl Cancer Inst Date: 1999-09-15 Impact factor: 13.506
Authors: Megan Neary; Catherine A Chappell; Kimberly K Scarsi; Shadia Nakalema; Joshua Matovu; Sharon L Achilles; Beatrice A Chen; Marco Siccardi; Andrew Owen; Mohammed Lamorde Journal: J Antimicrob Chemother Date: 2019-10-01 Impact factor: 5.790