Literature DB >> 26261557

Protective effects of luteolin against cognitive impairment induced by infusion of Aβ peptide in rats.

Tian-Xia Yu1, Peng Zhang2, Yan Guan3, Min Wang1, Ming-Qing Zhen2.   

Abstract

Luteolin can be found in many traditional Chinese medicines, it's a falconoid compound derived from Lonicera japonica Thunb. This study aims to investigate the neuroprotective effects of luteolin against cognitive impairment induced by amyloid-β (Aβ) peptide and the underlying mechanisms in rats. The animal behavioral tests showed that luteolin could ameliorate Aβ-induced learning and memory impairment. In hippocampal tissue, the activity of choline acetyl transferase (ChAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased after treated by luteolin. Luteolin also reversed the increased activity of acetylcholine esterase (AchE). In hippocampi homogenate, the content of acetylcholine (Ach) increased, but malondialdehyde (MDA) reduced. Moreover, luteolin can increase Bcl-2/Bax ratio. This study demonstrated that luteolin could protect Alzheimer's disease (AD) rats against Aβ-induced cognitive impairment through regulating the cholinergic system and inhibiting oxidative injuries. The results suggesting that luteolin may have potential as a therapy for AD.

Entities:  

Keywords:  Alzheimer’s disease; Aβ peptide; Luteolin; antioxidant activity; neuroprotection

Mesh：

Substances：

Year:  2015        PMID： 26261557      PMCID： PMC4525891     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  28 in total

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Authors:  F G Gervais; D Xu; G S Robertson; J P Vaillancourt; Y Zhu; J Huang; A LeBlanc; D Smith; M Rigby; M S Shearman; E E Clarke; H Zheng; L H Van Der Ploeg; S C Ruffolo; N A Thornberry; S Xanthoudakis; R J Zamboni; S Roy; D W Nicholson
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5.  Luteolin Inhibits Fibrillary β-Amyloid1-40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways.

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  9 in total

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