Literature DB >> 26259988

Menthol Content in US Marketed Cigarettes.

Jiu Ai1, Kenneth M Taylor2, Joseph G Lisko3, Hang Tran3, Clifford H Watson3, Matthew R Holman1.   

Abstract

INTRODUCTION: In 2011 menthol cigarettes accounted for 32 percent of the market in the United States, but there are few literature reports that provide measured menthol data for commercial cigarettes. To assess current menthol application levels in the US cigarette market, menthol levels in cigarettes labeled or not labeled to contain menthol was determined for a variety of contemporary domestic cigarette products.
METHOD: We measured the menthol content of 45 whole cigarettes using a validated gas chromatography/mass spectrometry method.
RESULTS: In 23 cigarette brands labeled as menthol products, the menthol levels of the whole cigarette ranged from 2.9 to 19.6mg/cigarette, with three products having higher levels of menthol relative to the other menthol products. The menthol levels for 22 cigarette products not labeled to contain menthol ranged from 0.002 to 0.07mg/cigarette. The type of packaging (soft vs. hard pack) for a given cigarette product does not appear to affect menthol levels based on the current limited data.
CONCLUSIONS: Menthol levels in cigarette products labeled as containing menthol are approximately 50- to 5000-fold higher than those in cigarette products not labeled as containing menthol. In general, menthol content appears to occur within discrete ranges for both mentholated and nonmentholated cigarettes. IMPLICATIONS: This study shows that menthol may be present in non-mentholated cigarettes and adds to the understanding of how menthol may be used in cigarette products. It is the first systematic study from the same laboratory which will readily enable comparison among menthol and non-menthol cigarettes.
© The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Year:  2015        PMID: 26259988      PMCID: PMC4747842          DOI: 10.1093/ntr/ntv162

Source DB:  PubMed          Journal:  Nicotine Tob Res        ISSN: 1462-2203            Impact factor:   4.244


  9 in total

Review 1.  A review and assessment of menthol employed as a cigarette flavoring ingredient.

Authors:  J Daniel Heck
Journal:  Food Chem Toxicol       Date:  2010-01       Impact factor: 6.023

2.  Application of headspace solid phase microextraction to qualitative and quantitative analysis of tobacco additives in cigarettes.

Authors:  Careen Merckel; Fritz Pragst; Astrid Ratzinger; Beat Aebi; Werner Bernhard; Frank Sporkert
Journal:  J Chromatogr A       Date:  2006-03-31       Impact factor: 4.759

3.  Effect of cigarette menthol content on mainstream smoke emissions.

Authors:  S M Gordon; M C Brinkman; R Q Meng; G M Anderson; J C Chuang; R R Kroeger; I L Reyes; P I Clark
Journal:  Chem Res Toxicol       Date:  2011-09-19       Impact factor: 3.739

4.  Characterization of measured menthol in 48 U.S. cigarette sub-brands.

Authors:  Carolyn C Celebucki; Geoffrey Ferris Wayne; Gregory N Connolly; James F Pankow; Elsa I Chang
Journal:  Nicotine Tob Res       Date:  2005-08       Impact factor: 4.244

5.  Quantitation of Ten Flavor Compounds in Unburned Tobacco Products.

Authors:  Joseph G Lisko; Stephen B Stanfill; Clifford H Watson
Journal:  Anal Methods       Date:  2014       Impact factor: 2.896

Review 6.  Continual smoking of mentholated cigarettes may mask the early warning symptoms of respiratory disease.

Authors:  Samuel Garten; R Victor Falkner
Journal:  Prev Med       Date:  2003-10       Impact factor: 4.018

7.  Tobacco industry control of menthol in cigarettes and targeting of adolescents and young adults.

Authors:  Jennifer M Kreslake; Geoffrey Ferris Wayne; Hillel R Alpert; Howard K Koh; Gregory N Connolly
Journal:  Am J Public Health       Date:  2008-07-16       Impact factor: 9.308

8.  Epidemiology of menthol cigarette use.

Authors:  Gary A Giovino; Stephen Sidney; Joseph C Gfroerer; Patrick M O'Malley; Jane A Allen; Patricia A Richter; K Michael Cummings
Journal:  Nicotine Tob Res       Date:  2004-02       Impact factor: 4.244

Review 9.  Menthol pharmacology and its potential impact on cigarette smoking behavior.

Authors:  Karen Ahijevych; Bridgette E Garrett
Journal:  Nicotine Tob Res       Date:  2004-02       Impact factor: 4.244

  9 in total
  27 in total

1.  Adolescent menthol cigarette use and risk of nicotine dependence: Findings from the national Population Assessment on Tobacco and Health (PATH) study.

Authors:  Sam N Cwalina; Anuja Majmundar; Jennifer B Unger; Jessica L Barrington-Trimis; Mary Ann Pentz
Journal:  Drug Alcohol Depend       Date:  2019-11-15       Impact factor: 4.492

2.  Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats.

Authors:  Erin Harrison; Lisa Biswas; Ramachandram Avusula; Meiyu Zhang; Yongzhen Gong; Xiu Liu
Journal:  Psychopharmacology (Berl)       Date:  2017-09-16       Impact factor: 4.530

3.  Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers.

Authors:  Kenneth A Perkins; Nicole Kunkle; Joshua L Karelitz
Journal:  Psychopharmacology (Berl)       Date:  2017-02-16       Impact factor: 4.530

4.  Enhancing effect of menthol on nicotine self-administration in rats.

Authors:  Lisa Biswas; Erin Harrison; Yongzhen Gong; Ramachandram Avusula; Jonathan Lee; Meiyu Zhang; Thomas Rousselle; Janice Lage; Xiu Liu
Journal:  Psychopharmacology (Berl)       Date:  2016-07-29       Impact factor: 4.530

5.  Menthol blunts the interoceptive discriminative stimulus effects of nicotine in female but not male rats.

Authors:  Y Wendy Huynh; Anthony Raimondi; Andrew Finkner; Jordan D Kuck; Carly Selleck; Rick A Bevins
Journal:  Psychopharmacology (Berl)       Date:  2020-05-24       Impact factor: 4.530

6.  Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences.

Authors:  Deniz Bagdas; Asti Jackson; Moriah Carper; Rita Yu-Tzu Chen; Lois S Akinola; M Imad Damaj
Journal:  Neuropharmacology       Date:  2020-08-20       Impact factor: 5.250

7.  Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL.

Authors:  Shannon Kozlovich; Gang Chen; Christy J W Watson; William J Blot; Philip Lazarus
Journal:  Drug Metab Dispos       Date:  2019-10-02       Impact factor: 3.922

8.  Menthol in electronic cigarettes: A contributor to respiratory disease?

Authors:  Vijayalekshmi Nair; Malcolm Tran; Rachel Z Behar; Song Zhai; Xinping Cui; Rattapol Phandthong; Yuhuan Wang; Songqin Pan; Wentai Luo; James F Pankow; David C Volz; Prue Talbot
Journal:  Toxicol Appl Pharmacol       Date:  2020-09-17       Impact factor: 4.219

9.  Effect of electric heating and ice added to the bowl on mainstream waterpipe semivolatile furan and other toxicant yields.

Authors:  Marielle C Brinkman; Andreas A Teferra; Noura O Kassem; Nada Of Kassem
Journal:  Tob Control       Date:  2019-09-21       Impact factor: 7.552

10.  Characterization of SPECTRUM Variable Nicotine Research Cigarettes.

Authors:  Patricia Richter; Pappas R Steven; Roberto Bravo; Joseph G Lisko; Maria Damian; Nathalie Gonzalez-Jimenez; Naudia Gray; Lisa M Keong; Jacob B Kimbrell; Peter Kuklenyik; Tameka S Lawler; Grace E Lee; Magaly Mendez; Jose Perez; Shakia Smith; Hang Tran; Robert Tyx; Clifford H Watson
Journal:  Tob Regul Sci       Date:  2016
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