Christine A Curcio1, Chandrakumar Balaratnasingam2, Jeffrey D Messinger1, Lawrence A Yannuzzi3, K Bailey Freund4. 1. Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama. 2. LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; Vitreous-Retina-Macula Consultants of New York, New York, New York; Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Sciences, Lions Eye Institute, The University of Western Australia, Perth, Australia. 3. LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; Vitreous-Retina-Macula Consultants of New York, New York, New York. 4. LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; Vitreous-Retina-Macula Consultants of New York, New York, New York; Department of Ophthalmology, New York University School of Medicine, New York, New York. Electronic address: kbfnyf@aol.com.
Abstract
PURPOSE: To correlate postmortem histology with previously recorded multimodal imaging from a patient with type 1 neovascularization (NV) associated with an acquired vitelliform lesion in the setting of age-related macular degeneration (AMD). DESIGN: Case study. METHODS: Multimodal imaging that was obtained antemortem was matched with ex vivo and high-resolution histologic images of the preserved donor macula. Anatomic correlates for multimodal imaging findings were then defined. RESULTS: Spectral-domain optical coherence tomography (OCT) revealed a split in the retinal pigment epithelium-Bruch membrane band. Type 1 NV in this case was composed of 6 layered components: (1) retinal pigment epithelium, (2) basal laminar deposits, (3) fibrovascular membrane, (4) fibrocellular scar, (5) hemorrhage, and (6) Bruch membrane. The anatomic correlates for the hyporeflective band on spectral-domain OCT included a thick basal laminar deposit. Not all structures could be readily separated on the basis of their reflectivity patterns. CONCLUSIONS: This is an important clinicopathologic correlation of NV secondary to AMD in the spectral-domain OCT era. Our findings of 6 layers include and extend the anatomic framework encapsulated by the double-layer and triple-layer signs. The resolution of current devices does not always permit distinction of the different layers of NV tissue. Thick basal laminar deposits may appear hyporeflective on spectral-domain OCT and may be confused with fluid from a neovascular process. It will be important to perform a larger clinicopathologic series to aid our anatomic interpretation of spectral-domain OCT images.
PURPOSE: To correlate postmortem histology with previously recorded multimodal imaging from a patient with type 1 neovascularization (NV) associated with an acquired vitelliform lesion in the setting of age-related macular degeneration (AMD). DESIGN: Case study. METHODS: Multimodal imaging that was obtained antemortem was matched with ex vivo and high-resolution histologic images of the preserved donor macula. Anatomic correlates for multimodal imaging findings were then defined. RESULTS: Spectral-domain optical coherence tomography (OCT) revealed a split in the retinal pigment epithelium-Bruch membrane band. Type 1 NV in this case was composed of 6 layered components: (1) retinal pigment epithelium, (2) basal laminar deposits, (3) fibrovascular membrane, (4) fibrocellular scar, (5) hemorrhage, and (6) Bruch membrane. The anatomic correlates for the hyporeflective band on spectral-domain OCT included a thick basal laminar deposit. Not all structures could be readily separated on the basis of their reflectivity patterns. CONCLUSIONS: This is an important clinicopathologic correlation of NV secondary to AMD in the spectral-domain OCT era. Our findings of 6 layers include and extend the anatomic framework encapsulated by the double-layer and triple-layer signs. The resolution of current devices does not always permit distinction of the different layers of NV tissue. Thick basal laminar deposits may appear hyporeflective on spectral-domain OCT and may be confused with fluid from a neovascular process. It will be important to perform a larger clinicopathologic series to aid our anatomic interpretation of spectral-domain OCT images.
Authors: Chandrakumar Balaratnasingam; Jeffrey D Messinger; Kenneth R Sloan; Lawrence A Yannuzzi; K Bailey Freund; Christine A Curcio Journal: Ophthalmology Date: 2017-01-30 Impact factor: 12.079
Authors: Emma C Zanzottera; Thomas Ach; Carrie Huisingh; Jeffrey D Messinger; K Bailey Freund; Christine A Curcio Journal: Retina Date: 2016-12 Impact factor: 4.256
Authors: Almut Bindewald-Wittich; Joanna Dolar-Szczasny; Sandrine H Kuenzel; Leon von der Emde; Maximilian Pfau; Robert Rejdak; Steffen Schmitz-Valckenberg; Thomas Ach; Jens Dreyhaupt; Frank G Holz Journal: Eye (Lond) Date: 2022-05-17 Impact factor: 3.775
Authors: Anna C S Tan; Polina Astroz; Kunal K Dansingani; Jason S Slakter; Lawrence A Yannuzzi; Christine A Curcio; K Bailey Freund Journal: Invest Ophthalmol Vis Sci Date: 2017-04-01 Impact factor: 4.799
Authors: Chandrakumar Balaratnasingam; Lawrence A Yannuzzi; Christine A Curcio; William H Morgan; Giuseppe Querques; Vittorio Capuano; Eric Souied; Jesse Jung; K Bailey Freund Journal: Invest Ophthalmol Vis Sci Date: 2016-10-01 Impact factor: 4.799
Authors: Christine A Curcio; Emma C Zanzottera; Thomas Ach; Chandrakumar Balaratnasingam; K Bailey Freund Journal: Invest Ophthalmol Vis Sci Date: 2017-05-01 Impact factor: 4.799
Authors: J Alan Gambril; Kenneth R Sloan; Thomas A Swain; Carrie Huisingh; Anna V Zarubina; Jeffrey D Messinger; Thomas Ach; Christine A Curcio Journal: Invest Ophthalmol Vis Sci Date: 2019-06-03 Impact factor: 4.799