Fernanda N Kaufmann1, Marta Gazal2, Thaíse C Mondin1, Taiane A Cardoso1, Luciana Á Quevedo1, Luciano D M Souza1, Karen Jansen1, Elizandra Braganhol3, Jean P Oses1, Ricardo T Pinheiro1, Manuella P Kaster4, Ricardo A da Silva1, Gabriele Ghisleni5. 1. Programa de Pós-Graduação em Saúde e Comportamento - Universidade Católica de Pelotas, Pelotas, RS, Brazil. 2. Biologia Celular e Molecular-Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. 3. Departamento de Bioquímica-Fundação Universidade Federal de Ciências da Saúde e de Porto Alegre, Porto Alegre, RS, Brazil. 4. Departamento de Bioquímica-Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. 5. Programa de Pós-Graduação em Saúde e Comportamento - Universidade Católica de Pelotas, Pelotas, RS, Brazil. Electronic address: ghisleni.g@gmail.com.
Abstract
INTRODUCTION: Studies have already pointed out the contribution of oxidative stress in the pathophysiology of major depressive disorder (MDD). The aim of the present study was to investigate the oxidative-antioxidative systems in MDD and in response to cognitive psychotherapies. Oxidative stress were analyzed in 49 MDD patients at baseline, post-treatment, and follow-up; and 49 control subjects without history of psychiatric disorders. RESULTS: MDD subjects presented an increase in oxidative damage related to control subjects for thiobarbituric acid reactive species (TBARS), nitric oxide, and a decrease in total thiol content. Cognitive psychotherapies were able to counteract peripheral oxidative stress in MDD patients, reducing TBARS levels (p<0.001) in the follow-up, nitric oxide (p<0.001) in the post-treatment and follow-up, and increasing the total thiol content (p<0.01) in the post-treatment and follow-up. CONCLUSION: Oxidative stress was associated with MDD and the regulation of these parameters might represent an important mechanism associated with the clinical improvement of cognitive psychotherapy.
INTRODUCTION: Studies have already pointed out the contribution of oxidative stress in the pathophysiology of major depressive disorder (MDD). The aim of the present study was to investigate the oxidative-antioxidative systems in MDD and in response to cognitive psychotherapies. Oxidative stress were analyzed in 49 MDDpatients at baseline, post-treatment, and follow-up; and 49 control subjects without history of psychiatric disorders. RESULTS:MDD subjects presented an increase in oxidative damage related to control subjects for thiobarbituric acid reactive species (TBARS), nitric oxide, and a decrease in total thiol content. Cognitive psychotherapies were able to counteract peripheral oxidative stress in MDDpatients, reducing TBARS levels (p<0.001) in the follow-up, nitric oxide (p<0.001) in the post-treatment and follow-up, and increasing the total thiol content (p<0.01) in the post-treatment and follow-up. CONCLUSION: Oxidative stress was associated with MDD and the regulation of these parameters might represent an important mechanism associated with the clinical improvement of cognitive psychotherapy.
Authors: Juan Francisco Rodríguez-Landa; León Jesús German-Ponciano; Abraham Puga-Olguín; Oscar Jerónimo Olmos-Vázquez Journal: Molecules Date: 2022-05-31 Impact factor: 4.927
Authors: Ana Paula Vargas Visentin; Rafael Colombo; Ellen Scotton; Débora Soligo Fracasso; Adriane Ribeiro da Rosa; Catia Santos Branco; Mirian Salvador Journal: Oxid Med Cell Longev Date: 2020-04-14 Impact factor: 6.543
Authors: Kristoffer N T Månsson; Daniel Lindqvist; Liu L Yang; Cecilia Svanborg; Josef Isung; Gustav Nilsonne; Lise Bergman-Nordgren; Samir El Alaoui; Erik Hedman-Lagerlöf; Martin Kraepelien; Jens Högström; Gerhard Andersson; Carl-Johan Boraxbekk; Håkan Fischer; Catharina Lavebratt; Owen M Wolkowitz; Tomas Furmark Journal: Transl Psychiatry Date: 2019-12-19 Impact factor: 6.222