Jung Won Moon1, Jang Pyo Bae2, Ho Yun Lee3, Namkug Kim4, Man Pyo Chung5, Hye Yun Park5, Yongjun Chang2, Joon Beom Seo2, Kyung Soo Lee6. 1. Department of Radiology (J.W.M.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. 2. Department of Radiology (J.P.B., N.K., Y.C., J.B.S.), Asan Medical Center, University of Ulsan College of Medicine, #88, Olympic-Ro, 43-gil, Songpa-gu, Seoul, 138-736, Korea. 3. Department of Radiology and Center for Imaging Science (H.Y.L., K.S.L.), Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 135-710, Korea. hoyunlee96@gmail.com. 4. Department of Radiology (J.P.B., N.K., Y.C., J.B.S.), Asan Medical Center, University of Ulsan College of Medicine, #88, Olympic-Ro, 43-gil, Songpa-gu, Seoul, 138-736, Korea. namkugkim@gmail.com. 5. Department of Pulmonology (M.P.C, H.Y.P), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 6. Department of Radiology and Center for Imaging Science (H.Y.L., K.S.L.), Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 135-710, Korea.
Abstract
OBJECTIVES: To evaluate automated texture-based segmentation of dual-energy CT (DECT) images in diffuse interstitial lung disease (DILD) patients and prognostic stratification by overlapping morphologic and perfusion information of total lung. METHODS: Suspected DILD patients scheduled for surgical biopsy were prospectively included. Texture patterns included ground-glass opacity (GGO), reticulation and consolidation. Pattern- and perfusion-based CT measurements were assessed to extract quantitative parameters. Accuracy of texture-based segmentation was analysed. Correlations between CT measurements and pulmonary function test or 6-minute walk test (6MWT) were calculated. Parameters of idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) and non-IPF/UIP were compared. Survival analysis was performed. RESULTS: Overall accuracy was 90.47% for whole lung segmentation. Correlations between mean iodine values of total lung, 50-97.5th (%) attenuation and forced vital capacity or 6MWT were significant. Volume of GGO, reticulation and consolidation had significant correlation with DLco or SpO2 on 6MWT. Significant differences were noted between IPF/UIP and non-IPF/UIP in 6MWT distance, mean iodine value of total lung, 25-75th (%) attenuation and entropy. IPF/UIP diagnosis, GGO ratio, DILD extent, 25-75th (%) attenuation and SpO2 on 6MWT showed significant correlations with survival. CONCLUSION: DECT combined with pattern analysis is useful for analysing DILD and predicting survival by provision of morphology and enhancement. KEY POINTS: • Dual-energy CT (DECT) produces morphologic and parenchymal enhancement information. • Automated lung segmentation enables analysis of disease extent and severity. • This prospective study showed value of DECT in DILD patients. • Parameters on DECT enable characterization and survival prediction of DILD.
OBJECTIVES: To evaluate automated texture-based segmentation of dual-energy CT (DECT) images in diffuse interstitial lung disease (DILD) patients and prognostic stratification by overlapping morphologic and perfusion information of total lung. METHODS: Suspected DILD patients scheduled for surgical biopsy were prospectively included. Texture patterns included ground-glass opacity (GGO), reticulation and consolidation. Pattern- and perfusion-based CT measurements were assessed to extract quantitative parameters. Accuracy of texture-based segmentation was analysed. Correlations between CT measurements and pulmonary function test or 6-minute walk test (6MWT) were calculated. Parameters of idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) and non-IPF/UIP were compared. Survival analysis was performed. RESULTS: Overall accuracy was 90.47% for whole lung segmentation. Correlations between mean iodine values of total lung, 50-97.5th (%) attenuation and forced vital capacity or 6MWT were significant. Volume of GGO, reticulation and consolidation had significant correlation with DLco or SpO2 on 6MWT. Significant differences were noted between IPF/UIP and non-IPF/UIP in 6MWT distance, mean iodine value of total lung, 25-75th (%) attenuation and entropy. IPF/UIP diagnosis, GGO ratio, DILD extent, 25-75th (%) attenuation and SpO2 on 6MWT showed significant correlations with survival. CONCLUSION: DECT combined with pattern analysis is useful for analysing DILD and predicting survival by provision of morphology and enhancement. KEY POINTS: • Dual-energy CT (DECT) produces morphologic and parenchymal enhancement information. • Automated lung segmentation enables analysis of disease extent and severity. • This prospective study showed value of DECT in DILD patients. • Parameters on DECT enable characterization and survival prediction of DILD.
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