Literature DB >> 26250739

Immunopathology of multiple sclerosis.

Calliope A Dendrou1, Lars Fugger1,2, Manuel A Friese3.   

Abstract

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.

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Mesh：

Year:  2015        PMID： 26250739     DOI： 10.1038/nri3871

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  121 in total

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Review 2.  Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses.

Authors:  Lazaros Belbasis; Vanesa Bellou; Evangelos Evangelou; John P A Ioannidis; Ioanna Tzoulaki
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3.  A case-control study of multiple sclerosis.

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Journal:  Immunity       Date:  2012-08-16       Impact factor: 31.745

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6.  IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

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7.  Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function.

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Journal:  Science       Date:  2014-08-21       Impact factor: 47.728

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10.  The relation between inflammation and neurodegeneration in multiple sclerosis brains.

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Authors:  Ralf Baron; Donna M Ferriero; Giovanni B Frisoni; Chetan Bettegowda; Ziya L Gokaslan; John A Kessler; Annamaria Vezzani; Stephen G Waxman; Sven Jarius; Brigitte Wildemann; Michael Weller
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Authors:  Angela M Mitchell; Aimon A Alkanani; Kristen A McDaniel; Laura Pyle; Kathleen Waugh; Andrea K Steck; Maki Nakayama; Liping Yu; Peter A Gottlieb; Marian J Rewers; Aaron W Michels
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Review 5.  The Gut Microbiome and Multiple Sclerosis.

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Journal:  Cold Spring Harb Perspect Med       Date:  2018-06-01       Impact factor: 6.915

6.  Pericytes modulate myelination in the central nervous system.

Authors:  Patrick O Azevedo; Isadora F G Sena; Julia P Andreotti; Juliana Carvalho-Tavares; José C Alves-Filho; Thiago M Cunha; Fernando Q Cunha; Akiva Mintz; Alexander Birbrair
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7.  Biochemically altered myelin triggers autoimmune demyelination.

Authors:  Andrew V Caprariello; James A Rogers; Megan L Morgan; Vahid Hoghooghi; Jason R Plemel; Adam Koebel; Shigeki Tsutsui; Jeffrey F Dunn; Lakshmi P Kotra; Shalina S Ousman; V Wee Yong; Peter K Stys
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-04       Impact factor: 11.205

Review 8.  Melatonin and Multiple Sclerosis: From Plausible Neuropharmacological Mechanisms of Action to Experimental and Clinical Evidence.

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Review 9.  The role of B cells in the immunopathogenesis of multiple sclerosis.

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Journal:  Cell       Date:  2020-04-03       Impact factor: 41.582
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