Literature DB >> 26250459

RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.

Guo Xiang1, Yang Yi1, He Weiwei1, Wu Weiming2.   

Abstract

RND1 is reported to control the dynamics of cytoskeleton, cell growth, and survival, and dysregulation of RND1 is involved in the tumorigenesis. However, its expression and functions in the esophageal squamous cell carcinoma (ESCC) are unknown. In the present study, it was found that the expression of RND1 was up-regulated in ESCC tissues compared with the adjacent normal tissues. Forced expression of RND1 promoted the growth and migration of ESCC cells, while knocking down the expression of RND1 inhibited the growth, migration, and metastasis of ESCC cells. Molecular mechanism studies showed that RND1 activated ERK signaling. In summary, our study suggested that RND1 plays an important role in the progression of ESCC, and RND1 might be a promising target for the treatment of ESCC.

Entities:  

Keywords:  Cell growth and migration; ERK signaling; ESCC; RND1

Mesh：

Substances：

Year:  2015        PMID： 26250459     DOI： 10.1007/s13277-015-3855-7

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  22 in total

Review 1.  Rnd proteins: a new family of Rho-related proteins that interfere with the assembly of filamentous actin structures and cell adhesion.

Authors:  P Chardin
Journal:  Prog Mol Subcell Biol       Date:  1999

2.  Tiam1 siRNA enhanced the sensitivity of sorafenib on esophageal squamous cell carcinoma in vivo.

Authors:  Huaimin Liu; Xin Wang; Guirong Shi; Lifeng Jiang; Xiaoli Liu
Journal:  Tumour Biol       Date:  2014-05-23

Review 3.  Rho GTPases in embryonic development.

Authors:  Philippe M Duquette; Nathalie Lamarche-Vane
Journal:  Small GTPases       Date:  2014

4.  RhoE functions as a tumor suppressor in esophageal squamous cell carcinoma and modulates the PTEN/PI3K/Akt signaling pathway.

Authors:  Hui Zhao; Jianping Yang; Tianli Fan; Shenglei Li; Xuequn Ren
Journal:  Tumour Biol       Date:  2012-04-03

5.  The GTPase-deficient Rnd proteins are stabilized by their effectors.

Authors:  Liuh Ling Goh; Ed Manser
Journal:  J Biol Chem       Date:  2012-07-17       Impact factor: 5.157

6.  Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization.

Authors:  Yuxiao Wang; Huawei He; Nishi Srivastava; Sheikh Vikarunnessa; Yong-bin Chen; Jin Jiang; Christopher W Cowan; Xuewu Zhang
Journal:  Sci Signal       Date:  2012-01-17       Impact factor: 8.192

Review 7.  Rho/ROCK signaling in motility and metastasis of gastric cancer.

Authors:  Tasuku Matsuoka; Masakazu Yashiro
Journal:  World J Gastroenterol       Date:  2014-10-14       Impact factor: 5.742

8.  ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways.

Authors:  Christiane D Fichter; Verena Gudernatsch; Camilla M Przypadlo; Marie Follo; Gudula Schmidt; Martin Werner; Silke Lassmann
Journal:  J Mol Med (Berl)       Date:  2014-08-06       Impact factor: 4.599

9.  The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.

Authors:  Liuh Ling Goh; Ed Manser
Journal:  PLoS One       Date:  2010-08-25       Impact factor: 3.240

10.  Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal squamous cell carcinoma.

Authors:  Xiaobin Cui; Su Li; Tingting Li; Xuelian Pang; Shumao Zhang; Jing Jin; Jianming Hu; Chunxia Liu; Lan Yang; Hao Peng; Jinfang Jiang; Weihua Liang; Jing Suo; Feng Li; Yunzhao Chen
Journal:  Int J Clin Exp Pathol       Date:  2014-04-15
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  2 in total

Review 1.  Pathophysiological functions of Rnd proteins.

Authors:  Sara Basbous; Roberta Azzarelli; Emilie Pacary; Violaine Moreau
Journal:  Small GTPases       Date:  2020-10-15

2.  RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma.

Authors:  Sabrina Boyrie; Caroline Delmas; Anthony Lemarié; Vincent Lubrano; Perrine Dahan; Laure Malric; José Luis; Julia Gilhodes; Marie Tosolini; Laetitia Mouly; Maxime Lehmann; Christine Toulas; Elizabeth Cohen-Jonathan Moyal; Sylvie Monferran
Journal:  Oncotarget       Date:  2018-09-18
  2 in total

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