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Literature DB >> 25483305

Rho GTPases in embryonic development.

Philippe M Duquette¹, Nathalie Lamarche-Vane.

Abstract

In the last decade, several mouse models for RhoA, Rac1, and Cdc42 have emerged and have contributed a great deal to understanding the precise functions of Rho GTPases at early stages of development. This review summarizes our current knowledge of various mouse models of tissue-specific ablation of Cdc42, Rac1, and RhoA with emphasis on early embryogenesis, epithelial and skin morphogenesis, tubulogenesis, development of the central nervous system, and limb development.

Entities: Gene Species

Keywords: Cdc42; Rac1; RhoA; cell fate; cell migration; cell polarity; cytoskeleton; embryonic development; mouse models; tubulogenesis

Mesh：

Substances：

Year: 2014 PMID： 25483305 PMCID： PMC4601498 DOI： 10.4161/sgtp.29716

Source DB: PubMed Journal: Small GTPases ISSN： 2154-1248

71 in total

Review 1. Rho GTPases in cell biology.

Authors: Sandrine Etienne-Manneville; Alan Hall
Journal: Nature Date: 2002-12-12 Impact factor: 49.962

2. Rac1 is required for the formation of three germ layers during gastrulation.

Authors: K Sugihara; N Nakatsuji; K Nakamura; K Nakao; R Hashimoto; H Otani; H Sakagami; H Kondo; S Nozawa; A Aiba; M Katsuki
Journal: Oncogene Date: 1998-12-31 Impact factor: 9.867

3. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

Authors: A J Ridley; A Hall
Journal: Cell Date: 1992-08-07 Impact factor: 41.582

4. Cdc42-mediated tubulogenesis controls cell specification.

Authors: Gokul Kesavan; Fredrik Wolfhagen Sand; Thomas Uwe Greiner; Jenny Kristina Johansson; Sune Kobberup; Xunwei Wu; Cord Brakebusch; Henrik Semb
Journal: Cell Date: 2009-11-13 Impact factor: 41.582

5. Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells.

Authors: Xiaodong Li; Etienne Saint-Cyr-Proulx; Klaus Aktories; Nathalie Lamarche-Vane
Journal: J Biol Chem Date: 2002-02-13 Impact factor: 5.157

6. Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies.

Authors: Laura Southgate; Rajiv D Machado; Katie M Snape; Martin Primeau; Dimitra Dafou; Deborah M Ruddy; Peter A Branney; Malcolm Fisher; Grace J Lee; Michael A Simpson; Yi He; Teisha Y Bradshaw; Bettina Blaumeiser; William S Winship; Willie Reardon; Eamonn R Maher; David R FitzPatrick; Wim Wuyts; Martin Zenker; Nathalie Lamarche-Vane; Richard C Trembath
Journal: Am J Hum Genet Date: 2011-05-13 Impact factor: 11.025

7. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome.

Authors: Ranad Shaheen; Eissa Faqeih; Asma Sunker; Heba Morsy; Tarfa Al-Sheddi; Hanan E Shamseldin; Nouran Adly; Mais Hashem; Fowzan S Alkuraya
Journal: Am J Hum Genet Date: 2011-08-04 Impact factor: 11.025

8. Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse.

Authors: Isabelle Migeotte; Tatiana Omelchenko; Alan Hall; Kathryn V Anderson
Journal: PLoS Biol Date: 2010-08-03 Impact factor: 8.029

Review 9. Axon guidance at the midline: of mice and flies.

Authors: Timothy A Evans; Greg J Bashaw
Journal: Curr Opin Neurobiol Date: 2010-01-14 Impact factor: 6.627

10. RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.

Authors: Ben Jackson; Karine Peyrollier; Esben Pedersen; Astrid Basse; Richard Karlsson; Zhipeng Wang; Tine Lefever; Alexandra M Ochsenbein; Gudula Schmidt; Klaus Aktories; Alanna Stanley; Fabio Quondamatteo; Markus Ladwein; Klemens Rottner; Jolanda van Hengel; Cord Brakebusch
Journal: Mol Biol Cell Date: 2011-01-05 Impact factor: 4.138

24 in total

Review 1. Signaling filopodia in vertebrate embryonic development.

Authors: Felicitas Pröls; Martin Scaal
Journal: Cell Mol Life Sci Date: 2015-11-30 Impact factor: 9.261

2. RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.

Authors: Guo Xiang; Yang Yi; He Weiwei; Wu Weiming
Journal: Tumour Biol Date: 2015-08-07

3. Rho GTPases at the crossroad of signaling networks in mammals.

Authors: Jean Claude Hervé; Nicolas Bourmeyster
Journal: Small GTPases Date: 2015-06-25

4. Reduced Hippocampal Dendrite Branching, Spine Density and Neurocognitive Function in Premature Rabbits, and Reversal with Estrogen or TrkB Agonist Treatment.

Authors: Damon Klebe; Mahima Tibrewal; Deep R Sharma; Rachna Vanaparthy; Sunil Krishna; Merina Varghese; Bokun Cheng; Peter R Mouton; Jana Velíšková; Kostantin Dobrenis; Patrick R Hof; Praveen Ballabh
Journal: Cereb Cortex Date: 2019-12-17 Impact factor: 5.357

5. Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients.

Authors: H-B Wang; H-C Yan; Y Liu
Journal: Clin Transl Oncol Date: 2015-10-26 Impact factor: 3.405

Review 6. Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease.

Authors: Keith Richard Mitchelson; Wen-Yan Qin
Journal: World J Biol Chem Date: 2015-08-26

7. RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.

Authors: Margot R F Reijnders; Nurhuda M Ansor; Maria Kousi; Wyatt W Yue; Perciliz L Tan; Katie Clarkson; Jill Clayton-Smith; Ken Corning; Julie R Jones; Wayne W K Lam; Grazia M S Mancini; Carlo Marcelis; Shehla Mohammed; Rolph Pfundt; Maian Roifman; Ronald Cohn; David Chitayat; Tom H Millard; Nicholas Katsanis; Han G Brunner; Siddharth Banka
Journal: Am J Hum Genet Date: 2017-09-07 Impact factor: 11.025