Literature DB >> 26249231

EBOLA VACCINE. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain.

Andrea Marzi1, Shelly J Robertson1, Elaine Haddock1, Friederike Feldmann2, Patrick W Hanley2, Dana P Scott2, James E Strong3, Gary Kobinger3, Sonja M Best1, Heinz Feldmann4.   

Abstract

The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the assessment of experimental therapeutics and vaccines in clinical trials. One of those vaccines is based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (VSV-EBOV), a live-attenuated vector with marked preclinical efficacy. Here, we provide the preclinical proof that VSV-EBOV completely protects macaques against lethal challenge with the West African EBOV-Makona strain. Complete and partial protection was achieved with a single dose given as late as 7 and 3 days before challenge, respectively. This indicates that VSV-EBOV may protect humans against EBOV infections in West Africa with relatively short time to immunity, promoting its use for immediate public health responses.
Copyright © 2015, American Association for the Advancement of Science.

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Year:  2015        PMID： 26249231     DOI： 10.1126/science.aab3920

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  105 in total

1.  Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.

Authors:  Zachary A Bornholdt; Hannah L Turner; Charles D Murin; Wen Li; Devin Sok; Colby A Souders; Ashley E Piper; Arthur Goff; Joshua D Shamblin; Suzanne E Wollen; Thomas R Sprague; Marnie L Fusco; Kathleen B J Pommert; Lisa A Cavacini; Heidi L Smith; Mark Klempner; Keith A Reimann; Eric Krauland; Tillman U Gerngross; Karl D Wittrup; Erica Ollmann Saphire; Dennis R Burton; Pamela J Glass; Andrew B Ward; Laura M Walker
Journal:  Science       Date:  2016-02-18       Impact factor: 47.728

2.  Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors.

Authors:  Manu Anantpadma; Jennifer Kouznetsova; Hang Wang; Ruili Huang; Andrey Kolokoltsov; Rajarshi Guha; Aaron R Lindstrom; Olena Shtanko; Anton Simeonov; David J Maloney; Wendy Maury; Douglas J LaCount; Ajit Jadhav; Robert A Davey
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

3.  A single dose of a vesicular stomatitis virus-based influenza vaccine confers rapid protection against H5 viruses from different clades.

Authors:  Wakako Furuyama; Pierce Reynolds; Elaine Haddock; Kimberly Meade-White; Mai Quynh Le; Yoshihiro Kawaoka; Heinz Feldmann; Andrea Marzi
Journal:  NPJ Vaccines       Date:  2020-01-10       Impact factor: 7.344

4.  An Adenovirus Vaccine Expressing Ebola Virus Variant Makona Glycoprotein Is Efficacious in Guinea Pigs and Nonhuman Primates.

Authors:  Shipo Wu; Andrea Kroeker; Gary Wong; Shihua He; Lihua Hou; Jonathan Audet; Haiyan Wei; Zhe Zhang; Lisa Fernando; Geoff Soule; Kaylie Tran; Shengli Bi; Tao Zhu; Xuefeng Yu; Wei Chen; Xiangguo Qiu
Journal:  J Infect Dis       Date:  2016-08-04       Impact factor: 5.226

Review 5.  What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? The Importance of Bridging Studies and Species-Independent Correlates of Protection.

Authors:  Hana Golding; Surender Khurana; Marina Zaitseva
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-04-02       Impact factor: 10.005

Review 6.  From bench to almost bedside: the long road to a licensed Ebola virus vaccine.

Authors:  Gary Wong; Emelissa J Mendoza; Francis A Plummer; George F Gao; Gary P Kobinger; Xiangguo Qiu
Journal:  Expert Opin Biol Ther       Date:  2017-11-17       Impact factor: 4.388

7.  Ebola virus encodes a miR-155 analog to regulate importin-α5 expression.

Authors:  Yuanwu Liu; Jing Sun; Hongwen Zhang; Mingming Wang; George Fu Gao; Xiangdong Li
Journal:  Cell Mol Life Sci       Date:  2016-04-19       Impact factor: 9.261

8.  Development of an Immunochromatography Assay (QuickNavi-Ebola) to Detect Multiple Species of Ebolaviruses.

Authors:  Reiko Yoshida; Shino Muramatsu; Hiroshi Akita; Yuji Saito; Miwa Kuwahara; Daisuke Kato; Katendi Changula; Hiroko Miyamoto; Masahiro Kajihara; Rashid Manzoor; Wakako Furuyama; Andrea Marzi; Heinz Feldmann; Aaron Mweene; Justin Masumu; Jimmy Kapeteshi; Jean-Jacques Muyembe-Tamfum; Ayato Takada
Journal:  J Infect Dis       Date:  2016-07-26       Impact factor: 5.226

Review 9.  Post-exposure treatments for Ebola and Marburg virus infections.

Authors:  Robert W Cross; Chad E Mire; Heinz Feldmann; Thomas W Geisbert
Journal:  Nat Rev Drug Discov       Date:  2018-01-29       Impact factor: 84.694

10.  Efficacy of Vesicular Stomatitis Virus-Ebola Virus Postexposure Treatment in Rhesus Macaques Infected With Ebola Virus Makona.

Authors:  Andrea Marzi; Patrick W Hanley; Elaine Haddock; Cynthia Martellaro; Gary Kobinger; Heinz Feldmann
Journal:  J Infect Dis       Date:  2016-08-05       Impact factor: 5.226
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