Literature DB >> 26248359

A Novel Y319H Substitution in CYP51C Associated with Azole Resistance in Aspergillus flavus.

R A Paul1, S M Rudramurthy1, J F Meis2, J W Mouton2, A Chakrabarti3.   

Abstract

This study aimed to explore any mutation in the CYP51 gene conferring azole resistance in Aspergillus flavus. Two voriconazole-resistant and 45 voriconazole-susceptible isolates were included in the study. Sequence analysis demonstrated a T1025C nucleotide change in CYP51C, resulting in the Y319H amino acid substitution in one resistant isolate. However, the earlier described T788G mutation in CYP51C conferring voriconazole resistance in A. flavus isolates was present in all isolates, irrespective of their susceptibility status.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26248359      PMCID： PMC4576050          DOI： 10.1128/AAC.00637-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing.

Authors:  Shivaprakash M Rudramurthy; Arunaloke Chakrabarti; Erik Geertsen; Johan W Mouton; Jacques F Meis
Journal:  Diagn Microbiol Infect Dis       Date:  2011-09-19       Impact factor: 2.803

2.  In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs.

Authors:  M R Shivaprakash; Erik Geertsen; Arunaloke Chakrabarti; Johan W Mouton; Jacques F Meis
Journal:  Mycoses       Date:  2011-04-25       Impact factor: 4.377

3.  The T788G mutation in the cyp51C gene confers voriconazole resistance in Aspergillus flavus causing aspergillosis.

Authors:  Wei Liu; Yi Sun; Wei Chen; Weixia Liu; Zhe Wan; Dingfang Bu; Ruoyu Li
Journal:  Antimicrob Agents Chemother       Date:  2012-02-06       Impact factor: 5.191

4.  Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

Authors:  Jun Wang; Chunlong Ma; Giacomo Fiorin; Vincenzo Carnevale; Tuo Wang; Fanghao Hu; Robert A Lamb; Lawrence H Pinto; Mei Hong; Michael L Klein; William F DeGrado
Journal:  J Am Chem Soc       Date:  2011-07-21       Impact factor: 15.419

Review 5.  The emerging epidemiology of mould infections in developing countries.

Authors:  Arunaloke Chakrabarti; Rachna Singh
Journal:  Curr Opin Infect Dis       Date:  2011-12       Impact factor: 4.915

6.  Cryptic speciation and recombination in the aflatoxin-producing fungus Aspergillus flavus.

Authors:  D M Geiser; J I Pitt; J W Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

7.  The structure-function relationship of the Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: the mechanism of L98H azole resistance.

Authors:  Eveline Snelders; Anna Karawajczyk; Rob J A Verhoeven; Hanka Venselaar; Gijs Schaftenaar; Paul E Verweij; Willem J G Melchers
Journal:  Fungal Genet Biol       Date:  2011-08-30       Impact factor: 3.495

8.  Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.

Authors:  Anuradha Chowdhary; Shallu Kathuria; Harbans S Randhawa; Shailendra N Gaur; Corné H Klaassen; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2011-10-25       Impact factor: 5.790

9.  Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes.

Authors:  N L Glass; G C Donaldson
Journal:  Appl Environ Microbiol       Date:  1995-04       Impact factor: 4.792

10.  Understanding the basis of drug resistance of the mutants of αβ-tubulin dimer via molecular dynamics simulations.

Authors:  Kathiresan Natarajan; Sanjib Senapati
Journal:  PLoS One       Date:  2012-08-07       Impact factor: 3.240
View more
  28 in total

1.  Microsatellite Typing and Resistance Mechanism Analysis of Voriconazole-Resistant Aspergillus flavus Isolates in South Korean Hospitals.

Authors:  Min Ji Choi; Eun Jeong Won; Min Young Joo; Yeon-Joon Park; Soo Hyun Kim; Myung Geun Shin; Jong Hee Shin
Journal:  Antimicrob Agents Chemother       Date:  2019-01-29       Impact factor: 5.191

Review 2.  Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.

Authors:  Jacques F Meis; Anuradha Chowdhary; Johanna L Rhodes; Matthew C Fisher; Paul E Verweij
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-05       Impact factor: 6.237

3.  Investigation of Multiple Resistance Mechanisms in Voriconazole-Resistant Aspergillus flavus Clinical Isolates from a Chest Hospital Surveillance in Delhi, India.

Authors:  Cheshta Sharma; Rakesh Kumar; Nitin Kumar; Aradhana Masih; Dinesh Gupta; Anuradha Chowdhary
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

4.  Genetic Diversity and In Vitro Antifungal Susceptibility of 200 Clinical and Environmental Aspergillus flavus Isolates.

Authors:  Mojtaba Taghizadeh-Armaki; Mohammad Taghi Hedayati; Saham Ansari; Saeed Mahdavi Omran; Sasan Saber; Haleh Rafati; Jan Zoll; Henrich A van der Lee; Willem J G Melchers; Paul E Verweij; Seyedmojtaba Seyedmousavi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

5.  Pharmacodynamics of Voriconazole against Wild-Type and Azole-Resistant Aspergillus flavus Isolates in a Nonneutropenic Murine Model of Disseminated Aspergillosis.

Authors:  Shivaprakash M Rudramurthy; Seyedmojtaba Seyedmousavi; Manpreet Dhaliwal; Arunaloke Chakrabarti; Jacques F Meis; Johan W Mouton
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

6.  Molecular Identification, Antifungal Susceptibility Testing, and Mechanisms of Azole Resistance in Aspergillus Species Received within a Surveillance Program on Antifungal Resistance in Spain.

Authors:  Olga Rivero-Menendez; Juan Carlos Soto-Debran; Narda Medina; Jose Lucio; Emilia Mellado; Ana Alastruey-Izquierdo
Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

7.  Contributions of yap1 Mutation and Subsequent atrF Upregulation to Voriconazole Resistance in Aspergillus flavus.

Authors:  Yuuta Ukai; Miho Kuroiwa; Naoko Kurihara; Hiroki Naruse; Tomoyuki Homma; Hideki Maki; Akira Naito
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

8.  Magnitude of Voriconazole Resistance in Clinical and Environmental Isolates of Aspergillus flavus and Investigation into the Role of Multidrug Efflux Pumps.

Authors:  Raees A Paul; Shivaprakash M Rudramurthy; Manpreet Dhaliwal; Pankaj Singh; Anup K Ghosh; Harsimran Kaur; Subhash Varma; Ritesh Agarwal; Arunaloke Chakrabarti
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

9.  New Insights into the Cyp51 Contribution to Azole Resistance in Aspergillus Section Nigri.

Authors:  Alba Pérez-Cantero; Loida López-Fernández; Josep Guarro; Javier Capilla
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

Review 10.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.