Literature DB >> 30397064

Microsatellite Typing and Resistance Mechanism Analysis of Voriconazole-Resistant Aspergillus flavus Isolates in South Korean Hospitals.

Min Ji Choi1, Eun Jeong Won2, Min Young Joo1, Yeon-Joon Park3, Soo Hyun Kim1, Myung Geun Shin1, Jong Hee Shin4.   

Abstract

A recent surveillance study in South Korea revealed that 14% (7/50) of Aspergillus flavus clinical isolates had a voriconazole minimum inhibitory concentration of ≥4 μg/ml. Of seven non-wild-type (non-WT) isolates, six ear isolates from four hospitals shared the same microsatellite genotype. None of the non-WT isolates showed cyp51 mutations associated with azole resistance. However, the mean expression levels of efflux pump (MDR2, atrF, and mfs1) and target (cyp51A) genes exhibited significant differences between non-WT and other isolates.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Aspergillus flavuszzm321990; azole resistance mechanism; gene expression

Mesh：

Substances：

Year:  2019        PMID： 30397064      PMCID： PMC6355573          DOI： 10.1128/AAC.01610-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

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Authors:  S Krishnan Natesan; A K Lamichchane; Subramanian Swaminathan; Wenjuan Wu
Journal:  Diagn Microbiol Infect Dis       Date:  2013-08       Impact factor: 2.803

2.  Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program.

Authors:  J Morgan; K A Wannemuehler; K A Marr; S Hadley; D P Kontoyiannis; T J Walsh; S K Fridkin; P G Pappas; D W Warnock
Journal:  Med Mycol       Date:  2005-05       Impact factor: 4.076

3.  In vitro antifungal susceptibilities of isolates of Candida spp. and Aspergillus spp. from China to nine systemically active antifungal agents: data from the SENTRY antifungal surveillance program, 2010 through 2012.

Authors:  Michael A Pfaller; Mariana Castanheira; Shawn A Messer; Ronald N Jones
Journal:  Mycoses       Date:  2015-02-27       Impact factor: 4.377

4.  Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India.

Authors:  Anuradha Chowdhary; Cheshta Sharma; Shallu Kathuria; Ferry Hagen; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2013-10-01       Impact factor: 5.790

Review 5.  The role of azoles in the management of azole-resistant aspergillosis: from the bench to the bedside.

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Journal:  Drug Resist Updat       Date:  2014-07-05       Impact factor: 18.500

6.  A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

Authors:  E Mellado; G Garcia-Effron; L Alcázar-Fuoli; W J G Melchers; P E Verweij; M Cuenca-Estrella; J L Rodríguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

7.  Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.

Authors:  Anuradha Chowdhary; Shallu Kathuria; Harbans S Randhawa; Shailendra N Gaur; Corné H Klaassen; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2011-10-25       Impact factor: 5.790

8.  Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Authors:  A J Ullmann; J M Aguado; S Arikan-Akdagli; D W Denning; A H Groll; K Lagrou; C Lass-Flörl; R E Lewis; P Munoz; P E Verweij; A Warris; F Ader; M Akova; M C Arendrup; R A Barnes; C Beigelman-Aubry; S Blot; E Bouza; R J M Brüggemann; D Buchheidt; J Cadranel; E Castagnola; A Chakrabarti; M Cuenca-Estrella; G Dimopoulos; J Fortun; J-P Gangneux; J Garbino; W J Heinz; R Herbrecht; C P Heussel; C C Kibbler; N Klimko; B J Kullberg; C Lange; T Lehrnbecher; J Löffler; O Lortholary; J Maertens; O Marchetti; J F Meis; L Pagano; P Ribaud; M Richardson; E Roilides; M Ruhnke; M Sanguinetti; D C Sheppard; J Sinkó; A Skiada; M J G T Vehreschild; C Viscoli; O A Cornely
Journal:  Clin Microbiol Infect       Date:  2018-03-12       Impact factor: 8.067

Review 9.  Update on antifungal resistance in Aspergillus and Candida.

Authors:  M C Arendrup
Journal:  Clin Microbiol Infect       Date:  2014-02-03       Impact factor: 8.067

Review 10.  Azole Resistance in Aspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?

Authors:  Paul E Verweij; Anuradha Chowdhary; Willem J G Melchers; Jacques F Meis
Journal:  Clin Infect Dis       Date:  2015-10-20       Impact factor: 9.079
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  8 in total

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Journal:  Stud Mycol       Date:  2021-05-10       Impact factor: 16.097

2.  Molecular Identification, Antifungal Susceptibility Testing, and Mechanisms of Azole Resistance in Aspergillus Species Received within a Surveillance Program on Antifungal Resistance in Spain.

Authors:  Olga Rivero-Menendez; Juan Carlos Soto-Debran; Narda Medina; Jose Lucio; Emilia Mellado; Ana Alastruey-Izquierdo
Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

Review 3.  Emerging Fungal Infections: New Patients, New Patterns, and New Pathogens.

Authors:  Daniel Z P Friedman; Ilan S Schwartz
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Review 4.  Invasive Aspergillosis by Aspergillus flavus: Epidemiology, Diagnosis, Antifungal Resistance, and Management.

Authors:  Shivaprakash M Rudramurthy; Raees A Paul; Arunaloke Chakrabarti; Johan W Mouton; Jacques F Meis
Journal:  J Fungi (Basel)       Date:  2019-07-01

5.  Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response.

Authors:  Dionysios Neofytos; Carolina Garcia-Vidal; Frédéric Lamoth; Christoph Lichtenstern; Alessandro Perrella; Jörg Janne Vehreschild
Journal:  BMC Infect Dis       Date:  2021-03-24       Impact factor: 3.090

6.  Genetic and Phenotypic Characterization of in-Host Developed Azole-Resistant Aspergillus flavus Isolates.

Authors:  Jochem B Buil; Jos Houbraken; Monique H Reijers; Jan Zoll; Maurizio Sanguinetti; Jacques F Meis; Paul E Verweij; Willem J G Melchers
Journal:  J Fungi (Basel)       Date:  2021-02-25

Review 7.  Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications.

Authors:  Thomas R Rogers; Paul E Verweij; Mariana Castanheira; Eric Dannaoui; P Lewis White; Maiken Cavling Arendrup
Journal:  J Antimicrob Chemother       Date:  2022-07-28       Impact factor: 5.758

8.  Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus.

Authors:  Jose Lucio; Irene Gonzalez-Jimenez; Olga Rivero-Menendez; Ana Alastruey-Izquierdo; Teresa Pelaez; Laura Alcazar-Fuoli; Emilia Mellado
Journal:  Genes (Basel)       Date:  2020-10-17       Impact factor: 4.096
  8 in total

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