Literature DB >> 26244929

NNMT: A Bad Actor in Fat Makes Good in Liver.

Samuel A J Trammell1, Charles Brenner2.   

Abstract

High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26244929      PMCID： PMC4768475          DOI： 10.1016/j.cmet.2015.07.017

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  9 in total

Review 1.  Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications.

Authors:  Sirisha Ghanta; Ruth E Grossmann; Charles Brenner
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-09-19       Impact factor: 8.250

Review 2.  SIRT1 and other sirtuins in metabolism.

Authors:  Hung-Chun Chang; Leonard Guarente
Journal:  Trends Endocrinol Metab       Date:  2013-12-30       Impact factor: 12.015

Review 3.  NAD+ metabolism in health and disease.

Authors:  Peter Belenky; Katrina L Bogan; Charles Brenner
Journal:  Trends Biochem Sci       Date:  2006-12-11       Impact factor: 13.807

4.  Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

Authors:  Joseph T Rodgers; Carlos Lerin; Wilhelm Haas; Steven P Gygi; Bruce M Spiegelman; Pere Puigserver
Journal:  Nature       Date:  2005-03-03       Impact factor: 49.962

5.  High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.

Authors:  Angeliki Chalkiadaki; Leonard Guarente
Journal:  Cell Metab       Date:  2012-08-08       Impact factor: 27.287

Review 6.  Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.

Authors:  Katrina L Bogan; Charles Brenner
Journal:  Annu Rev Nutr       Date:  2008       Impact factor: 11.848

7.  Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Authors:  Daniel Kraus; Qin Yang; Dong Kong; Alexander S Banks; Lin Zhang; Joseph T Rodgers; Eija Pirinen; Thomas C Pulinilkunnil; Fengying Gong; Ya-chin Wang; Yana Cen; Anthony A Sauve; John M Asara; Odile D Peroni; Brett P Monia; Sanjay Bhanot; Leena Alhonen; Pere Puigserver; Barbara B Kahn
Journal:  Nature       Date:  2014-04-10       Impact factor: 49.962

8.  Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.

Authors:  Shangyu Hong; Jose M Moreno-Navarrete; Xiaojing Wei; Yusuke Kikukawa; Iphigenia Tzameli; Deepthi Prasad; Yoonjin Lee; John M Asara; Jose Manuel Fernandez-Real; Eleftheria Maratos-Flier; Pavlos Pissios
Journal:  Nat Med       Date:  2015-07-13       Impact factor: 53.440

Review 9.  Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites.

Authors:  Samuel Aj Trammell; Charles Brenner
Journal:  Comput Struct Biotechnol J       Date:  2013-05-27       Impact factor: 7.271
  9 in total
  20 in total

1.  Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Authors:  Sarah J Mitchell; Michel Bernier; Miguel A Aon; Sonia Cortassa; Eun Young Kim; Evandro F Fang; Hector H Palacios; Ahmed Ali; Ignacio Navas-Enamorado; Andrea Di Francesco; Tamzin A Kaiser; Tyler B Waltz; Ning Zhang; James L Ellis; Peter J Elliott; David W Frederick; Vilhelm A Bohr; Mark S Schmidt; Charles Brenner; David A Sinclair; Anthony A Sauve; Joseph A Baur; Rafael de Cabo
Journal:  Cell Metab       Date:  2018-03-06       Impact factor: 27.287

Review 2.  Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.

Authors:  Pavlos Pissios
Journal:  Trends Endocrinol Metab       Date:  2017-03-11       Impact factor: 12.015

3.  NAD+ Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy.

Authors:  Krish Chandrasekaran; Neda Najimi; Avinash R Sagi; Sushuma Yarlagadda; Mohammad Salimian; Muhammed Ikbal Arvas; Ahmad F Hedayat; Yanni Kevas; Anand Kadakia; James W Russell
Journal:  Int J Mol Sci       Date:  2022-04-28       Impact factor: 6.208

Review 4.  NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential.

Authors:  Na Xie; Lu Zhang; Wei Gao; Canhua Huang; Peter Ernst Huber; Xiaobo Zhou; Changlong Li; Guobo Shen; Bingwen Zou
Journal:  Signal Transduct Target Ther       Date:  2020-10-07

Review 5.  Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes.

Authors:  Nady Braidy; Jade Berg; James Clement; Fatemeh Khorshidi; Anne Poljak; Tharusha Jayasena; Ross Grant; Perminder Sachdev
Journal:  Antioxid Redox Signal       Date:  2018-05-11       Impact factor: 8.401

6.  Accumulation of Nicotinamide N-Methyltransferase (NNMT) in Cancer-associated Fibroblasts: A Potential Prognostic and Predictive Biomarker for Gastric Carcinoma.

Authors:  Li Zhang; Mengmeng Song; Fan Zhang; Hao Yuan; Wenjun Chang; Guanyu Yu; Yongdong Niu
Journal:  J Histochem Cytochem       Date:  2020-12-07       Impact factor: 2.479

7.  Tissue-specific NETs alter genome organization and regulation even in a heterologous system.

Authors:  Jose I de Las Heras; Nikolaj Zuleger; Dzmitry G Batrakou; Rafal Czapiewski; Alastair R W Kerr; Eric C Schirmer
Journal:  Nucleus       Date:  2017-01-03       Impact factor: 4.197

Review 8.  Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.

Authors:  Renata Novak Kujundžić; Marin Prpić; Nikola Đaković; Nina Dabelić; Marko Tomljanović; Anamarija Mojzeš; Ana Fröbe; Koraljka Gall Trošelj
Journal:  Int J Mol Sci       Date:  2021-05-26       Impact factor: 5.923

9.  Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Obesity in Chinese Han Male College Students.

Authors:  Qiong Zhou; Xiao-Juan Zhu; Jiang-Hua Li
Journal:  Biomed Res Int       Date:  2017-09-18       Impact factor: 3.411

Review 10.  Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics.

Authors:  Adrian C Williams; Lisa J Hill
Journal:  Int J Tryptophan Res       Date:  2017-05-02
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