Literature DB >> 28291578

Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.

Pavlos Pissios1.   

Abstract

Nicotinamide (NAM) N-methyltransferase (NNMT) was originally identified as the enzyme responsible for the methylation of NAM, one of the forms of vitamin B3. Methylated NAM is eventually excreted from the body. Recent evidence has expanded the role of NNMT beyond clearance of excess vitamin B3. NNMT has been implicated in the regulation of multiple metabolic pathways in tissues such as adipose and liver as well as cancer cells through the consumption of methyl donors and generation of active metabolites. This review examines recent findings regarding the function of NNMT in physiology and disease and highlights potential new avenues for therapeutic intervention. Finally, key gaps in our knowledge about this enzymatic system and future areas of investigation are discussed.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28291578      PMCID： PMC5446048          DOI： 10.1016/j.tem.2017.02.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  86 in total

1.  Substrate specificity of nicotinamide methyltransferase isolated from porcine liver.

Authors:  T A Alston; R H Abeles
Journal:  Arch Biochem Biophys       Date:  1988-02-01       Impact factor: 4.013

2.  Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

Authors:  Kevin D Brown; Sadia Maqsood; Jing-Yi Huang; Yong Pan; William Harkcom; Wei Li; Anthony Sauve; Eric Verdin; Samie R Jaffrey
Journal:  Cell Metab       Date:  2014-12-02       Impact factor: 27.287

Review 3.  Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.

Authors:  Katrina L Bogan; Charles Brenner
Journal:  Annu Rev Nutr       Date:  2008       Impact factor: 11.848

4.  Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma.

Authors:  Davide Sartini; Andrea Santarelli; Valentina Rossi; Gaia Goteri; Corrado Rubini; Domenico Ciavarella; Lorenzo Lo Muzio; Monica Emanuelli
Journal:  Mol Med       Date:  2007 Jul-Aug       Impact factor: 6.354

Review 5.  NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy.

Authors:  Yue Yang; Anthony A Sauve
Journal:  Biochim Biophys Acta       Date:  2016-06-29

6.  NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability.

Authors:  Kamalakannan Palanichamy; Suman Kanji; Nicolaus Gordon; Krishnan Thirumoorthy; John R Jacob; Kevin T Litzenberg; Disha Patel; Arnab Chakravarti
Journal:  Clin Cancer Res       Date:  2016-11-03       Impact factor: 12.531

7.  Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Authors:  Daniel Kraus; Qin Yang; Dong Kong; Alexander S Banks; Lin Zhang; Joseph T Rodgers; Eija Pirinen; Thomas C Pulinilkunnil; Fengying Gong; Ya-chin Wang; Yana Cen; Anthony A Sauve; John M Asara; Odile D Peroni; Brett P Monia; Sanjay Bhanot; Leena Alhonen; Pere Puigserver; Barbara B Kahn
Journal:  Nature       Date:  2014-04-10       Impact factor: 49.962

8.  Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis.

Authors:  Jongmin Kim; Seok Joo Hong; Eun Kyung Lim; Yun-Suk Yu; Seung Whan Kim; Ji Hyeon Roh; In-Gu Do; Jae-Won Joh; Dae Shick Kim
Journal:  J Exp Clin Cancer Res       Date:  2009-02-16

9.  Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.

Authors:  Aimo Kannt; Anja Pfenninger; Lenore Teichert; Anke Tönjes; Arne Dietrich; Michael R Schön; Nora Klöting; Matthias Blüher
Journal:  Diabetologia       Date:  2015-01-18       Impact factor: 10.122

10.  SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

Authors:  Xiaoling Li; Songwen Zhang; Gil Blander; Jeanette G Tse; Monty Krieger; Leonard Guarente
Journal:  Mol Cell       Date:  2007-10-12       Impact factor: 17.970
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  68 in total

1.  BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents.

Authors:  Arun Kanakkanthara; Kiran Kurmi; Thomas L Ekstrom; Xiaonan Hou; Emma R Purfeerst; Ethan P Heinzen; Cristina Correia; Catherine J Huntoon; Daniel O'Brien; Andrea E Wahner Hendrickson; Sean C Dowdy; Hu Li; Ann L Oberg; Taro Hitosugi; Scott H Kaufmann; S John Weroha; Larry M Karnitz
Journal:  Cancer Res       Date:  2019-10-16       Impact factor: 12.701

2.  The Rheumatoid Arthritis-Associated Citrullinome.

Authors:  Ronak Tilvawala; Son Hong Nguyen; Aaron J Maurais; Venkatesh V Nemmara; Mitesh Nagar; Ari J Salinger; Sunil Nagpal; Eranthie Weerapana; Paul R Thompson
Journal:  Cell Chem Biol       Date:  2018-04-05       Impact factor: 8.116

3.  Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase.

Authors:  Iredia D Iyamu; Rong Huang
Journal:  Anal Biochem       Date:  2020-07-02       Impact factor: 3.365

Review 4.  NAD+ metabolism and its roles in cellular processes during ageing.

Authors:  Anthony J Covarrubias; Rosalba Perrone; Alessia Grozio; Eric Verdin
Journal:  Nat Rev Mol Cell Biol       Date:  2020-12-22       Impact factor: 94.444

5.  Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

Authors:  Nicolas Babault; Abdellah Allali-Hassani; Fengling Li; Jie Fan; Alex Yue; Kevin Ju; Feng Liu; Masoud Vedadi; Jing Liu; Jian Jin
Journal:  J Med Chem       Date:  2018-01-31       Impact factor: 7.446

6.  Identification of evolutionary and kinetic drivers of NAD-dependent signaling.

Authors:  Mathias Bockwoldt; Dorothée Houry; Marc Niere; Toni I Gossmann; Ines Reinartz; Alexander Schug; Mathias Ziegler; Ines Heiland
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-24       Impact factor: 11.205

7.  Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase.

Authors:  Dongxing Chen; Linjie Li; Krystal Diaz; Iredia D Iyamu; Ravi Yadav; Nicholas Noinaj; Rong Huang
Journal:  J Med Chem       Date:  2019-12-03       Impact factor: 7.446

8.  Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.

Authors:  Harshini Neelakantan; Camille R Brightwell; Ted G Graber; Rosario Maroto; Hua-Yu Leo Wang; Stanton F McHardy; John Papaconstantinou; Christopher S Fry; Stanley J Watowich
Journal:  Biochem Pharmacol       Date:  2019-02-10       Impact factor: 5.858

9.  Metabolic signature of the aging eye in mice.

Authors:  Yekai Wang; Allison Grenell; Fanyi Zhong; Michelle Yam; Allison Hauer; Elizabeth Gregor; Siyan Zhu; Daniel Lohner; Jiangjiang Zhu; Jianhai Du
Journal:  Neurobiol Aging       Date:  2018-08-07       Impact factor: 4.673

10.  Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-β1 expression.

Authors:  Liang Liang; Ming Zeng; Haixia Pan; Hao Liu; Yangke He
Journal:  Oncol Lett       Date:  2018-01-26       Impact factor: 2.967
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