Literature DB >> 2624431

Analysing rearrangement breakpoint distributions by means of binomial confidence intervals.

K Vasarhelyi1, J M Friedman.   

Abstract

Non-randomness in the distribution of rearrangement breakpoints can be assessed by means of a binomial probability model. Using the binomial model, we compute confidence intervals for the observed number of breakpoints in chromosome bands and use these confidence intervals to test for non-randomness in a set of 452 constitutional rearrangement breakpoints. This method is useful because it describes the observed data and is not dependent on comparison with a pre-existing hypothesis regarding the distribution.

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Year:  1989        PMID： 2624431     DOI： 10.1111/j.1469-1809.1989.tb01805.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  5 in total

1.  Identifying chromosomal fragile sites from individuals: a multinomial statistical model.

Authors:  U Böhm; P F Dahm; B F McAllister; I F Greenbaum
Journal:  Hum Genet       Date:  1995-03       Impact factor: 4.132

2.  A chromosomal duplication map of malformations: regions of suspected haplo- and triplolethality--and tolerance of segmental aneuploidy--in humans.

Authors:  C Brewer; S Holloway; P Zawalnyski; A Schinzel; D FitzPatrick
Journal:  Am J Hum Genet       Date:  1999-06       Impact factor: 11.025

3.  A locus for isolated cleft palate, located on human chromosome 2q32.

Authors:  C M Brewer; J P Leek; A J Green; S Holloway; D T Bonthron; A F Markham; D R FitzPatrick
Journal:  Am J Hum Genet       Date:  1999-08       Impact factor: 11.025

Review 4.  Detection of cryptic chromosomal abnormalities in unexplained mental retardation: a general strategy using hypervariable subtelomeric DNA polymorphisms.

Authors:  A O Wilkie
Journal:  Am J Hum Genet       Date:  1993-09       Impact factor: 11.025

5.  A chromosomal deletion map of human malformations.

Authors:  C Brewer; S Holloway; P Zawalnyski; A Schinzel; D FitzPatrick
Journal:  Am J Hum Genet       Date:  1998-10       Impact factor: 11.025
  5 in total

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