Giuseppe Lippi1, Camilla Mattiuzzi1, Massimo Franchini1. 1. 1 Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy ; 2 Service of Clinical Governance, General Hospital of Trento, Trento, Italy ; 3 Department of Hematology and Transfusion Medicine, C. Poma Hospital, Mantova, Italy.
Abstract
BACKGROUND: Among the various risk factors of venous thromboembolism (VTE), nutrients seem to play a significant role in the pathogenesis of this condition. This study aimed to clarify the relationship between coffee intake and venous thrombosis, and we performed a critical review of clinical studies that have been published so far. METHODS: An electronic search was carried out in Medline, Scopus and ISI Web of Science with the keywords "coffee" AND "venous thromboembolism" OR "deep vein thrombosis" OR "pulmonary embolism" in "Title/Abstract/Keywords", with no language and date restriction. RESULTS: According to our criteria, three studies (two prospective and one case-control) were finally selected (inter-study heterogeneity: 78%; P<0.001). Cumulative data suggests that a modest intake of coffee (i.e., 1-4 cups/day) may be associated with an 11% increased risk of VTE compared to abstainers, whereas a larger intake (i.e., ≥5 coffee/day) may be associated with a 25% decreased risk. CONCLUSIONS: Our analysis of published data seemingly confirm the existence of a U-shape relationship between coffee intake and VTE, thus exhibiting a trend that overlaps with that previously reported for cardiovascular disease (CVD).
BACKGROUND: Among the various risk factors of venous thromboembolism (VTE), nutrients seem to play a significant role in the pathogenesis of this condition. This study aimed to clarify the relationship between coffee intake and venous thrombosis, and we performed a critical review of clinical studies that have been published so far. METHODS: An electronic search was carried out in Medline, Scopus and ISI Web of Science with the keywords "coffee" AND "venous thromboembolism" OR "deep vein thrombosis" OR "pulmonary embolism" in "Title/Abstract/Keywords", with no language and date restriction. RESULTS: According to our criteria, three studies (two prospective and one case-control) were finally selected (inter-study heterogeneity: 78%; P<0.001). Cumulative data suggests that a modest intake of coffee (i.e., 1-4 cups/day) may be associated with an 11% increased risk of VTE compared to abstainers, whereas a larger intake (i.e., ≥5 coffee/day) may be associated with a 25% decreased risk. CONCLUSIONS: Our analysis of published data seemingly confirm the existence of a U-shape relationship between coffee intake and VTE, thus exhibiting a trend that overlaps with that previously reported for cardiovascular disease (CVD).
Authors: James H O'Keefe; Salman K Bhatti; Harshal R Patil; James J DiNicolantonio; Sean C Lucan; Carl J Lavie Journal: J Am Coll Cardiol Date: 2013-07-17 Impact factor: 24.094
Authors: R E J Roach; B Siegerink; S le Cessie; F R Rosendaal; S C Cannegieter; W M Lijfering Journal: J Thromb Haemost Date: 2012-12 Impact factor: 5.824