Literature DB >> 26239529

RB-loss puts focus on Myc.

Wayne O Miles1, Nicholas J Dyson1.   

Abstract

Activator E2Fs and Myc cooperate as master regulators of proliferation. A new study sheds light on one of the fundamental questions in cancer biology: how do oncogenic changes, such as Retinoblastoma (RB)-mutation, modify E2F and Myc activity?

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Year:  2015        PMID： 26239529     DOI： 10.1038/ncb3213

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

1.  A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.

Authors:  Xiaoqin Xu; Mark Bieda; Victor X Jin; Alina Rabinovich; Mathew J Oberley; Roland Green; Peggy J Farnham
Journal:  Genome Res       Date:  2007-10-01       Impact factor: 9.043

2.  The E2F transcription factor is a cellular target for the RB protein.

Authors:  S P Chellappan; S Hiebert; M Mudryj; J M Horowitz; J R Nevins
Journal:  Cell       Date:  1991-06-14       Impact factor: 41.582

3.  c-Myc regulates transcriptional pause release.

Authors:  Peter B Rahl; Charles Y Lin; Amy C Seila; Ryan A Flynn; Scott McCuine; Christopher B Burge; Phillip A Sharp; Richard A Young
Journal:  Cell       Date:  2010-04-30       Impact factor: 41.582

4.  Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc.

Authors:  E M Blackwood; R N Eisenman
Journal:  Science       Date:  1991-03-08       Impact factor: 47.728

5.  Division and apoptosis of E2f-deficient retinal progenitors.

Authors:  Danian Chen; Marek Pacal; Pamela Wenzel; Paul S Knoepfler; Gustavo Leone; Rod Bremner
Journal:  Nature       Date:  2009-12-17       Impact factor: 49.962

6.  Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product.

Authors:  A K Rustgi; N Dyson; R Bernards
Journal:  Nature       Date:  1991-08-08       Impact factor: 49.962

7.  A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

Authors:  Jonghwan Kim; Andrew J Woo; Jianlin Chu; Jonathan W Snow; Yuko Fujiwara; Chul Geun Kim; Alan B Cantor; Stuart H Orkin
Journal:  Cell       Date:  2010-10-15       Impact factor: 41.582

8.  Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.

Authors:  Huayang Liu; Xing Tang; Arunima Srivastava; Thierry Pécot; Piotr Daniel; Benjamin Hemmelgarn; Stephan Reyes; Nicholas Fackler; Amneet Bajwa; Raleigh Kladney; Christopher Koivisto; Zhong Chen; Qianben Wang; Kun Huang; Raghu Machiraju; Maria Teresa Sáenz-Robles; Paul Cantalupo; James M Pipas; Gustavo Leone
Journal:  Nat Cell Biol       Date:  2015-07-20       Impact factor: 28.824

9.  E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.

Authors:  Jean-Leon Chong; Pamela L Wenzel; M Teresa Sáenz-Robles; Vivek Nair; Antoney Ferrey; John P Hagan; Yorman M Gomez; Nidhi Sharma; Hui-Zi Chen; Madhu Ouseph; Shu-Huei Wang; Prashant Trikha; Brian Culp; Louise Mezache; Douglas J Winton; Owen J Sansom; Danian Chen; Rod Bremner; Paul G Cantalupo; Michael L Robinson; James M Pipas; Gustavo Leone
Journal:  Nature       Date:  2009-12-17       Impact factor: 49.962

10.  Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.

Authors:  R L Beijersbergen; E M Hijmans; L Zhu; R Bernards
Journal:  EMBO J       Date:  1994-09-01       Impact factor: 11.598
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  2 in total

1.  Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model.

Authors:  Xuguang Zhu; Keisuke Enomoto; Li Zhao; Yuelin J Zhu; Mark C Willingham; Paul Meltzer; Jun Qi; Sheue-Yann Cheng
Journal:  Clin Cancer Res       Date:  2016-07-20       Impact factor: 12.531

2.  Proteins associated with the doubling time of the NCI-60 cancer cell lines.

Authors:  Michael Polymenis
Journal:  Cell Div       Date:  2017-08-29       Impact factor: 5.130
  2 in total

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