Osamu Kainuma1, Fumihiko Miura2, Daisuke Furukawa3, Hiroshi Yamamoto4, Akihiro Cho4, Keiji Sano2, Toshio Nakagohri3, Takehide Asano5. 1. Department of Gastroenterological Surgery, Chiba Cancer Center, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan. okainuma@chiba-cc.jp. 2. Department of Surgery, Tokyo University School of Medicine, Tokyo, Japan. 3. Department of Surgery, Tokai University School of Medicine, Isehara, Japan. 4. Department of Gastroenterological Surgery, Chiba Cancer Center, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan. 5. Department of Surgery, National Hospital Organization Chiba-East Hospital, Chiba, Japan.
Abstract
BACKGROUND: The aim of this multi-institutional study was to assess the feasibility and the efficacy of gemcitabine plus cisplatin (CDDP) combination therapy (GC therapy) for biliary tract cancer (BTC) in the adjuvant setting. METHODS: Eligible patients identified between January 2008 and January 2013 were enrolled. GC therapy at 1,000 mg/m(2) of gemcitabine and 25 mg/m(2) of CDDP on days 1 and 8 repeated every 3 weeks was performed for 6 months. The primary endpoint was the feasibility and the adverse events, and the secondary endpoint was recurrence-free survival (RFS) and overall survival (OS). RESULTS: Among 29 evaluable patients, the protocol was completed in 21 (72%) patients. Relative dose intensity (RDI) of gemcitabine and CDDP was 77% and 81%, respectively. There was no difference in the completion rate and the RDI between patients who underwent resection with vs. without major hepatectomy. Grade 3-4 toxicities included leukopenia (14%) and neutropenia (27%). Two-year RFS and 2-year OS was 59% and 90%, respectively. CONCLUSIONS: Standard dose of GC therapy is tolerable in patients with BTC who underwent curative resection either with or without major hepatectomy. The survival effect of this regimen is promising, but further comparative study is needed.
BACKGROUND: The aim of this multi-institutional study was to assess the feasibility and the efficacy of gemcitabine plus cisplatin (CDDP) combination therapy (GC therapy) for biliary tract cancer (BTC) in the adjuvant setting. METHODS: Eligible patients identified between January 2008 and January 2013 were enrolled. GC therapy at 1,000 mg/m(2) of gemcitabine and 25 mg/m(2) of CDDP on days 1 and 8 repeated every 3 weeks was performed for 6 months. The primary endpoint was the feasibility and the adverse events, and the secondary endpoint was recurrence-free survival (RFS) and overall survival (OS). RESULTS: Among 29 evaluable patients, the protocol was completed in 21 (72%) patients. Relative dose intensity (RDI) of gemcitabine and CDDP was 77% and 81%, respectively. There was no difference in the completion rate and the RDI between patients who underwent resection with vs. without major hepatectomy. Grade 3-4 toxicities included leukopenia (14%) and neutropenia (27%). Two-year RFS and 2-year OS was 59% and 90%, respectively. CONCLUSIONS: Standard dose of GC therapy is tolerable in patients with BTC who underwent curative resection either with or without major hepatectomy. The survival effect of this regimen is promising, but further comparative study is needed.
Authors: Alexander R Siebenhüner; Heike Seifert; Helga Bachmann; Burkhardt Seifert; Thomas Winder; Jonas Feilchenfeldt; Stefan Breitenstein; Pierre-Alain Clavien; Roger Stupp; Alexander Knuth; Bernhard Pestalozzi; Panagiotis Samaras Journal: BMC Cancer Date: 2018-01-11 Impact factor: 4.430