Jan Willem Popma1, Frank W Snel2, Cees J Haagsma1, Petra Brummelhuis-Visser1, Hans G J Oldenhof1, Job van der Palen1, Mart A F J van de Laar1. 1. From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente. 2. From the departments of Rheumatology and Clinical Pharmacy of both Ziekenhuisgroep Twente, Almelo, and Medisch Spectrum Twente, Enschede, the Netherlands.J.W. Popma, MSc, clinical pharmacist; F.W. Snel, MSc, resident in rheumatology; C.J. Haagsma, PhD, rheumatologist; P. Brummelhuis-Visser, MSc, clinical pharmacist; H.G. Oldenhof, MSc, clinical pharmacist, Ziekenhuisgroep Twente; J. van der Palen, PhD, clinical epidemiologist, M.A. van de Laar, PhD, rheumatologist, Medisch Spectrum Twente. f.snel@zgt.nl.
Abstract
OBJECTIVE: To determine whether a double dose of intraarticular triamcinolone acetonide is more effective for knee arthritis than a 40-mg dose. METHODS: In this 12-week randomized controlled clinical trial, 40 mg and 80 mg of intraarticular triamcinolone acetonide were compared in patients with knee arthritis. Evaluated variables included a Likert burden scale, visual analog scale pain scale, degree of arthritis activity, presence of swelling, and presence of functional limitation. RESULTS:Ninety-seven patients were randomized. No significant differences were observed between the groups regarding any outcomes. CONCLUSION: An 80-mg dose of triamcinolone acetonide had no additional benefit compared with 40 mg as treatment for knee arthritis. TRIAL REGISTRATION: Nederlands Trial Register; trial registration number: NTR2298.
RCT Entities:
OBJECTIVE: To determine whether a double dose of intraarticular triamcinolone acetonide is more effective for knee arthritis than a 40-mg dose. METHODS: In this 12-week randomized controlled clinical trial, 40 mg and 80 mg of intraarticular triamcinolone acetonide were compared in patients with knee arthritis. Evaluated variables included a Likert burden scale, visual analog scale pain scale, degree of arthritis activity, presence of swelling, and presence of functional limitation. RESULTS: Ninety-seven patients were randomized. No significant differences were observed between the groups regarding any outcomes. CONCLUSION: An 80-mg dose of triamcinolone acetonide had no additional benefit compared with 40 mg as treatment for knee arthritis. TRIAL REGISTRATION: Nederlands Trial Register; trial registration number: NTR2298.
Entities:
Keywords:
ARTHRITIS; DOSE-RESPONSE RELATIONSHIP; DRUG THERAPY; INJECTIONS; INTRAARTICULAR; TRIAMCINOLONE
Authors: Imke Rudnik-Jansen; Anna R Tellegen; Behdad Pouran; Karin Schrijver; Björn P Meij; Pieter J Emans; Erin de Gendt; Rachel E Thomas; Marja J L Kik; Huub M de Visser; Harrie Weinans; Annelies Egas; Erik van Maarseveen; Nina Woike; George Mihov; Jens Thies; Marianna A Tryfonidou; Laura B Creemers Journal: Br J Pharmacol Date: 2019-10-08 Impact factor: 8.739