Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Recent advances in genome editing and creation of genetically modified pigs.

Literature DB >> 26231992

Recent advances in genome editing and creation of genetically modified pigs.

James R Butler¹, Joseph M Ladowski¹, Gregory R Martens¹, Matthew Tector¹, A Joseph Tector².

Abstract

The field of xenotransplantation is benefiting greatly from recent advances in genetic engineering. The efficiency and pace with which new model animals are being created has dramatically sped progress towards clinical relevance. Endonuclease-driven genome editing now allows for the efficient generation of targeted genetic alterations. Herein we review the available methods of genetic engineering that have been successfully employed to create genetically modified pigs.

Entities: Species

Keywords: Endonuclease; Homologous recombination; Off-target; TALEN CRISPR/Cas9; Zinc finger nuclease

Mesh：

Year: 2015 PMID： 26231992 DOI： 10.1016/j.ijsu.2015.07.684

Source DB: PubMed Journal: Int J Surg ISSN： 1743-9159 Impact factor: 6.071

Keyword Cloud
Cited

19 in total

1. Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation.

Authors: James R Butler; Gregory R Martens; Jose L Estrada; Luz M Reyes; Joseph M Ladowski; Cesare Galli; Andrea Perota; Conor M Cunningham; Matthew Tector; A Joseph Tector
Journal: Transgenic Res Date: 2016-04-21 Impact factor: 2.788

Review 2. Genetically-engineered pigs as sources for clinical red blood cell transfusion: What pathobiological barriers need to be overcome?

Authors: Benjamin Smood; Hidetaka Hara; Leah J Schoel; David K C Cooper
Journal: Blood Rev Date: 2019-01-28 Impact factor: 8.250

3. Early barriers to neonatal porcine islet engraftment in a dual transplant model.

Authors: K P Samy; R P Davis; Q Gao; B M Martin; M Song; J Cano; A B Farris; A McDonald; E K Gall; C R Dove; F V Leopardi; T How; K D Williams; G R Devi; B H Collins; A D Kirk
Journal: Am J Transplant Date: 2017-12-28 Impact factor: 8.086

4. Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers.

Authors: James Russell Butler; Leela L Paris; Ross L Blankenship; Richard A Sidner; Gregory R Martens; Joseph M Ladowski; Ping Li; Jose L Estrada; Matthew Tector; A Joseph Tector
Journal: Transplantation Date: 2016-03 Impact factor: 4.939

5. Swine Leukocyte Antigen Class II Is a Xenoantigen.

Authors: Joseph M Ladowski; Luz M Reyes; Gregory R Martens; James R Butler; Zheng-Yu Wang; Devin E Eckhoff; Matthew Tector; A Joseph Tector
Journal: Transplantation Date: 2018-02 Impact factor: 4.939

6. Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade.

Authors: J A Shah; M S Patel; N Elias; N Navarro-Alvarez; I Rosales; R A Wilkinson; N J Louras; M Hertl; J A Fishman; R B Colvin; A B Cosimi; J F Markmann; D H Sachs; P A Vagefi
Journal: Am J Transplant Date: 2017-06-06 Impact factor: 8.086

7. Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells.

Authors: Zhongqiang Zhang; Hidetaka Hara; Cassandra Long; Hayato Iwase; Haizhi Qi; Camila Macedo; Massimo Mangiola; Adriana Zeevi; Mohamed Ezzelarab; David Ayares; David K C Cooper; Martin Wijkstrom
Journal: Transplantation Date: 2018-05 Impact factor: 4.939