Christopher D Maroules1, Alice Y Chang, Melanie S Kotys-Traughber, Ronald M Peshock. 1. From the *Cardiothoracic Imaging Division, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX; †Division of Endocrinology, Metabolism, Diabetes and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN; ‡MR Clinical Science, Philips Healthcare, Cleveland, OH; and §Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Abstract
OBJECTIVE: The aim of this study was to determine if differences in coronary endothelial function are observed between asymptomatic women with type 2 diabetes mellitus (DM) and control subjects using coronary phase contrast flow velocity magnetic resonance imaging in response to cold pressor stress, an established endothelium-dependent vasodilatory stress. METHODS: Phase contrast flow velocity imaging of the right coronary artery was performed in 7 asymptomatic premenopausal women with DM and 8 healthy female participants in response to the cold pressor test at 3 T. RESULTS: There was no significant difference in percent increase in coronary flow velocity from rest to peak flow velocity between DM and control subjects (32% ± 22% vs 46% ± 17%; P = 0.11). However, percent increase in coronary flow velocity was lower in DM than in control subjects (-3% ± 14% vs 31% ± 30%; P = 0.01) during the second minute of cold pressor stress, when endothelial-mediated vasodilation should occur. CONCLUSIONS: Asymptomatic women with DM demonstrate reduced coronary flow velocity during the second minute of cold pressor stress, indicating coronary endothelial dysfunction.
OBJECTIVE: The aim of this study was to determine if differences in coronary endothelial function are observed between asymptomatic women with type 2 diabetes mellitus (DM) and control subjects using coronary phase contrast flow velocity magnetic resonance imaging in response to cold pressor stress, an established endothelium-dependent vasodilatory stress. METHODS: Phase contrast flow velocity imaging of the right coronary artery was performed in 7 asymptomatic premenopausal women with DM and 8 healthy female participants in response to the cold pressor test at 3 T. RESULTS: There was no significant difference in percent increase in coronary flow velocity from rest to peak flow velocity between DM and control subjects (32% ± 22% vs 46% ± 17%; P = 0.11). However, percent increase in coronary flow velocity was lower in DM than in control subjects (-3% ± 14% vs 31% ± 30%; P = 0.01) during the second minute of cold pressor stress, when endothelial-mediated vasodilation should occur. CONCLUSIONS: Asymptomatic women with DM demonstrate reduced coronary flow velocity during the second minute of cold pressor stress, indicating coronary endothelial dysfunction.
Authors: M Schiemann; F Bakhtiary; V Hietschold; A Koch; A Esmaeili; H Ackermann; A Moritz; T J Vogl; N D Abolmaali Journal: Eur Radiol Date: 2006-01-13 Impact factor: 5.315
Authors: John O Prior; Manuel J Quiñones; Miguel Hernandez-Pampaloni; Alvaro D Facta; Thomas H Schindler; James W Sayre; Willa A Hsueh; Heinrich R Schelbert Journal: Circulation Date: 2005-04-25 Impact factor: 29.690
Authors: Tina Ken Schramm; Gunnar H Gislason; Lars Køber; Søren Rasmussen; Jeppe N Rasmussen; Steen Z Abildstrøm; Morten Lock Hansen; Fredrik Folke; Pernille Buch; Mette Madsen; Allan Vaag; Christian Torp-Pedersen Journal: Circulation Date: 2008-03-31 Impact factor: 29.690