Literature DB >> 26229079

Seeing is believing: Ras dimers observed in live cells.

Mark R Philips1, Channing J Der2.   

Abstract

Mesh：

Substances：

Year:  2015        PMID： 26229079      PMCID： PMC4538609          DOI： 10.1073/pnas.1511805112

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


× No keyword cloud information.
  19 in total

1.  Formation of the Ras dimer is essential for Raf-1 activation.

Authors:  K Inouye; S Mizutani; H Koide; Y Kaziro
Journal:  J Biol Chem       Date:  2000-02-11       Impact factor: 5.157

2.  Structural determinants of Ras-Raf interaction analyzed in live cells.

Authors:  Tzvetanka Bondeva; András Balla; Péter Várnai; Tamas Balla
Journal:  Mol Biol Cell       Date:  2002-07       Impact factor: 4.138

3.  H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton.

Authors:  Sarah J Plowman; Cornelia Muncke; Robert G Parton; John F Hancock
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-13       Impact factor: 11.205

4.  Oligomeric structure of p21 ras proteins as determined by radiation inactivation.

Authors:  E Santos; A R Nebreda; T Bryan; E S Kempner
Journal:  J Biol Chem       Date:  1988-07-15       Impact factor: 5.157

5.  A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.

Authors:  Matthew R Whorton; Michael P Bokoch; Søren G F Rasmussen; Bo Huang; Richard N Zare; Brian Kobilka; Roger K Sunahara
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-23       Impact factor: 11.205

6.  H-Ras forms dimers on membrane surfaces via a protein-protein interface.

Authors:  Wan-Chen Lin; Lars Iversen; Hsiung-Lin Tu; Christopher Rhodes; Sune M Christensen; Jeffrey S Iwig; Scott D Hansen; William Y C Huang; Jay T Groves
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-10       Impact factor: 11.205

7.  Plasma membrane nanoswitches generate high-fidelity Ras signal transduction.

Authors:  Tianhai Tian; Angus Harding; Kerry Inder; Sarah Plowman; Robert G Parton; John F Hancock
Journal:  Nat Cell Biol       Date:  2007-07-08       Impact factor: 28.824

8.  A dimerization-dependent mechanism drives RAF catalytic activation.

Authors:  Thanashan Rajakulendran; Malha Sahmi; Martin Lefrançois; Frank Sicheri; Marc Therrien
Journal:  Nature       Date:  2009-09-02       Impact factor: 49.962

9.  RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Authors:  Poulikos I Poulikakos; Chao Zhang; Gideon Bollag; Kevan M Shokat; Neal Rosen
Journal:  Nature       Date:  2010-03-18       Impact factor: 49.962

10.  Direct visualization of Ras proteins in spatially distinct cell surface microdomains.

Authors:  Ian A Prior; Cornelia Muncke; Robert G Parton; John F Hancock
Journal:  J Cell Biol       Date:  2003-01-13       Impact factor: 10.539
View more
  7 in total

Review 1.  Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Authors:  Shaoyong Lu; Hyunbum Jang; Shuo Gu; Jian Zhang; Ruth Nussinov
Journal:  Chem Soc Rev       Date:  2016-07-11       Impact factor: 54.564

2.  Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders.

Authors:  Yao-Cheng Li; Nikki K Lytle; Seth T Gammon; Luke Wang; Tikvah K Hayes; Margie N Sutton; Robert C Bast; Channing J Der; David Piwnica-Worms; Frank McCormick; Geoffrey M Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-18       Impact factor: 11.205

3.  Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role.

Authors:  Abdallah Sayyed-Ahmad; Kwang-Jin Cho; John F Hancock; Alemayehu A Gorfe
Journal:  J Phys Chem B       Date:  2016-05-11       Impact factor: 2.991

4.  An Application of pET SUMO Protein Expression System in Escherichia coli: Cloning, Expression, Purification, and Characterisation of Native Kras4BG12V Oncoprotein.

Authors:  Michelle Siying Tan; Yuan Han Teh; Kok Lian Ho; Johnson Stanslas
Journal:  Protein J       Date:  2020-02       Impact factor: 2.371

Review 5.  Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.

Authors:  Mo Chen; Alec Peters; Tao Huang; Xiaolin Nan
Journal:  Mini Rev Med Chem       Date:  2016       Impact factor: 3.862

Review 6.  ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth.

Authors:  Christopher J Gilbert; Jacob Z Longenecker; Federica Accornero
Journal:  Biology (Basel)       Date:  2021-04-20

7.  KRAS is vulnerable to reversible switch-II pocket engagement in cells.

Authors:  James D Vasta; D Matthew Peacock; Qinheng Zheng; Joel A Walker; Ziyang Zhang; Chad A Zimprich; Morgan R Thomas; Michael T Beck; Brock F Binkowski; Cesear R Corona; Matthew B Robers; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2022-03-21       Impact factor: 16.174
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.