Literature DB >> 26228093

Safe and symptomatic medicinal use of surface-functionalized Mn3O4 nanoparticles for hyperbilirubinemia treatment in mice.

Nabarun Polley1, Srimoyee Saha2, Aniruddha Adhikari1, Somtirtha Banerjee2, Soumendra Darbar3, Sukhen Das2, Samir Kumar Pal1.   

Abstract

AIM: Testing the potential of citrate-capped Mn3O4 nanoparticles (NPs) as a therapeutic agent for alternative rapid treatment of hyperbilirubinemia through direct removal of bilirubin (BR) from blood in mice. MATERIALS &amp; <br> METHODS: NPs were synthesized and the mechanism of BR degradation in presence and absence of biological macromolecules were characterized in vitro. To test the in vivo BR degradation ability of NPs, CCl4-intoxicated mice were intraperitoneally injected with NPs. <br> RESULTS: We demonstrated ultrahigh efficacy of the NPs in symptomatic treatment of hyperbilirubinemia for rapid reduction of BR in mice compared with conventional medicine silymarin without any toxicological implications. <br> CONCLUSION: These findings may pave the way for practical clinical use of the NPs as safe medication of hyperbilirubinemia in human subjects.

Entities:  

Keywords:  Mn-based functionalized nanoparticles; hyperbilirubinemia; mice model; nanomedicine; nanotherapy of jaundice

Mesh：

Substances：

Year:  2015        PMID： 26228093     DOI： 10.2217/nnm.15.83

Source DB:  PubMed          Journal:  Nanomedicine (Lond)        ISSN： 1743-5889            Impact factor:   5.307


  6 in total

1.  Chemoprevention of bilirubin encephalopathy with a nanoceutical agent.

Authors:  Aniruddha Adhikari; Vinod K Bhutani; Susmita Mondal; Monojit Das; Soumendra Darbar; Ria Ghosh; Nabarun Polley; Anjan Kumar Das; Siddhartha Sankar Bhattacharya; Debasish Pal; Asim Kumar Mallick; Samir Kumar Pal
Journal:  Pediatr Res       Date:  2022-07-06       Impact factor: 3.756

2.  Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice.

Authors:  Aniruddha Adhikari; Susmita Mondal; Tanima Chatterjee; Monojit Das; Pritam Biswas; Ria Ghosh; Soumendra Darbar; Hussain Alessa; Jalal T Althakafy; Ali Sayqal; Saleh A Ahmed; Anjan Kumar Das; Maitree Bhattacharyya; Samir Kumar Pal
Journal:  Commun Biol       Date:  2021-08-26

3.  Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain.

Authors:  Yaswanth Kuthati; Prabhakar Busa; Venkata Naga Goutham Davuluri; Chih Shung Wong
Journal:  Int J Nanomedicine       Date:  2019-12-27

4.  Novel one pot synthesis and spectroscopic characterization of a folate-Mn3O4 nanohybrid for potential photodynamic therapeutic application.

Authors:  Susmita Mondal; Aniruddha Adhikari; Monojit Das; Soumendra Darbar; Ahmed Alharbi; Saleh A Ahmed; Siddhartha Sankar Bhattacharya; Debasish Pal; Samir Kumar Pal
Journal:  RSC Adv       Date:  2019-09-24       Impact factor: 4.036

5.  Citrate functionalized Mn3O4 in nanotherapy of hepatic fibrosis by oral administration.

Authors:  Aniruddha Adhikari; Nabarun Polley; Soumendra Darbar; Damayanti Bagchi; Samir Kumar Pal
Journal:  Future Sci OA       Date:  2016-10-06

6.  Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors.

Authors:  Animesh Halder; Aniruddha Adhikari; Ria Ghosh; Soumendra Singh; Amrita Banerjee; Nilanjana Ghosh; Arnab Madhab Bhattacharya; Shrabani Mandal; Prantar Chakrabarti; Debasis Bhattacharyya; Hatem M Altass; Moataz Morad; Saleh A Ahmed; Asim Kumar Mallick; Samir Kumar Pal
Journal:  Sci Rep       Date:  2020-07-07       Impact factor: 4.379
  6 in total

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