Literature DB >> 26224401

Associations Between Genetic Variants of the Natriuretic Peptide System and Blood Pressure Response to Dietary Sodium Intervention: The GenSalt Study.

Shufeng Chen1, Jianfeng Huang2, Qi Zhao3, Jing Chen3, Cashell E Jaquish4, Jiang He3, Xiangfeng Lu2, Xueli Yang2, Charles C Gu5, James E Hixson6, Fangchao Liu2, Treva K Rice5, Jie Cao2, Jichun Chen2, Dongfeng Gu2.   

Abstract

BACKGROUND: The aim of this study was to comprehensively test the association of genetic variants in the natriuretic peptide (NP) system with blood pressure (BP) response to dietary sodium intervention in a Chinese population.
METHODS: We conducted a 7-day low-sodium intervention followed by a 7-day high-sodium intervention among 1,906 participants in rural China. BP measurements were obtained at baseline and each dietary intervention using a random-zero sphygmomanometer. Linear mixed-effect models were used to assess the associations of 48 single-nucleotide polymorphisms (SNPs) in 6 genes of NP system with BP response to dietary sodium intervention.
RESULTS: SNP rs5063 in the NPPA gene and SNP rs2077386 in the NPPC gene exhibited significant associations with BP response to low-sodium dietary intervention under recessive genetic model. For rs5063, absolute mean arterial pressure responses (95% confidence interval) to the low-sodium intervention were 1.31 (-1.08, 3.70) mm Hg for TT genotype and -3.74 (-4.01, -3.46) mm Hg for CC or TC genotype, respectively (P = 4.1 × 10(-5)). Individuals with at least one copy of the C allele of rs2077386 had significantly reduction in systolic BP during the low-sodium intervention compared to those with genotype GG with responses of -5.48 (-5.83, -5.14) vs. -2.76 (-3.52, -2.00) mm Hg, respectively (P = 1.9 × 10(-13)).
CONCLUSIONS: These novel findings suggested that genetic variants of NP system may contribute to the variation of BP response to sodium intervention in Chinese population. Certainly, replication of these results in other populations and further functional studies are warranted to clarify their role in the regulation of BP and hypertension. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  blood pressure response; dietary intervention; genetic association; natriuretic peptide.

Mesh：

Substances：

Year:  2015        PMID： 26224401      PMCID： PMC4757957          DOI： 10.1093/ajh/hpv129

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN： 0895-7061            Impact factor:   2.689


  40 in total

1.  Association of natriuretic peptide receptor-C gene with ischemic stroke and hypertension in Chinese Han population.

Authors:  Ying Liu; Shuyuan Li; Xingdong Chen; Lijuan Zheng; Yajun Yang; Li Jin; Xiaofeng Wang
Journal:  Clin Exp Hypertens       Date:  2012-05-04       Impact factor: 1.749

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Journal:  Am J Clin Nutr       Date:  1997-02       Impact factor: 7.045

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Authors:  N Matsukawa; W J Grzesik; N Takahashi; K N Pandey; S Pang; M Yamauchi; O Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

5.  Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study.

Authors:  Jiang He; Dongfeng Gu; Jing Chen; Cashell E Jaquish; Dabeeru C Rao; James E Hixson; Ji-chun Chen; Xiufang Duan; Jian-feng Huang; Chung-Shiuan Chen; Tanika N Kelly; Lydia A Bazzano; Paul K Whelton
Journal:  J Hypertens       Date:  2009-01       Impact factor: 4.844

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Authors:  Tanja Zeller; Philipp Wild; Silke Szymczak; Maxime Rotival; Arne Schillert; Raphaele Castagne; Seraya Maouche; Marine Germain; Karl Lackner; Heidi Rossmann; Medea Eleftheriadis; Christoph R Sinning; Renate B Schnabel; Edith Lubos; Detlev Mennerich; Werner Rust; Claire Perret; Carole Proust; Viviane Nicaud; Joseph Loscalzo; Norbert Hübner; David Tregouet; Thomas Münzel; Andreas Ziegler; Laurence Tiret; Stefan Blankenberg; François Cambien
Journal:  PLoS One       Date:  2010-05-18       Impact factor: 3.240

7.  Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts.

Authors:  Takeshi Horio; Takeshi Tokudome; Toshiyuki Maki; Fumiki Yoshihara; Shin-Ichi Suga; Toshio Nishikimi; Masayasu Kojima; Yuhei Kawano; Kenji Kangawa
Journal:  Endocrinology       Date:  2003-06       Impact factor: 4.736

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Authors:  M H Weinberger
Journal:  Endocr Res       Date:  1991       Impact factor: 1.720

9.  Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

Authors:  David Conen; Suzanne Cheng; Lori L Steiner; Julie E Buring; Paul M Ridker; Robert Y L Zee
Journal:  J Hypertens       Date:  2009-03       Impact factor: 4.844

10.  Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:  Georg B Ehret; Patricia B Munroe; Kenneth M Rice; Murielle Bochud; Andrew D Johnson; Daniel I Chasman; Albert V Smith; Martin D Tobin; Germaine C Verwoert; Shih-Jen Hwang; Vasyl Pihur; Peter Vollenweider; Paul F O'Reilly; Najaf Amin; Jennifer L Bragg-Gresham; Alexander Teumer; Nicole L Glazer; Lenore Launer; Jing Hua Zhao; Yurii Aulchenko; Simon Heath; Siim Sõber; Afshin Parsa; Jian'an Luan; Pankaj Arora; Abbas Dehghan; Feng Zhang; Gavin Lucas; Andrew A Hicks; Anne U Jackson; John F Peden; Toshiko Tanaka; Sarah H Wild; Igor Rudan; Wilmar Igl; Yuri Milaneschi; Alex N Parker; Cristiano Fava; John C Chambers; Ervin R Fox; Meena Kumari; Min Jin Go; Pim van der Harst; Wen Hong Linda Kao; Marketa Sjögren; D G Vinay; Myriam Alexander; Yasuharu Tabara; Sue Shaw-Hawkins; Peter H Whincup; Yongmei Liu; Gang Shi; Johanna Kuusisto; Bamidele Tayo; Mark Seielstad; Xueling Sim; Khanh-Dung Hoang Nguyen; Terho Lehtimäki; Giuseppe Matullo; Ying Wu; Tom R Gaunt; N Charlotte Onland-Moret; Matthew N Cooper; 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James F Wilson; Luigi Ferrucci; Martin Farrall; Jaakko Tuomilehto; Peter P Pramstaller; Roberto Elosua; Nicole Soranzo; Eric J G Sijbrands; David Altshuler; Ruth J F Loos; Alan R Shuldiner; Christian Gieger; Pierre Meneton; Andre G Uitterlinden; Nicholas J Wareham; Vilmundur Gudnason; Jerome I Rotter; Rainer Rettig; Manuela Uda; David P Strachan; Jacqueline C M Witteman; Anna-Liisa Hartikainen; Jacques S Beckmann; Eric Boerwinkle; Ramachandran S Vasan; Michael Boehnke; Martin G Larson; Marjo-Riitta Järvelin; Bruce M Psaty; Gonçalo R Abecasis; Aravinda Chakravarti; Paul Elliott; Cornelia M van Duijn; Christopher Newton-Cheh; Daniel Levy; Mark J Caulfield; Toby Johnson
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962
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  1 in total

Review 1.  Sodium sensitivity of blood pressure in Chinese populations.

Authors:  Yang Liu; Mengyao Shi; Jacquelyn Dolan; Jiang He
Journal:  J Hum Hypertens       Date:  2019-01-10       Impact factor: 3.012
  1 in total

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