Charlotte K Lautrup1, Ellen M Mikkelsen2, Timothy L Lash3, Niels Katballe4, Lone Sunde5. 1. Department of Clinical Genetics, Aarhus University Hospital, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Denmark; Department of Clinical Genetics, Aalborg University Hospital, Denmark; The HNPCC Register, Clinical Research Center, Copenhagen University Hospital, Denmark. Electronic address: charlaut@rm.dk. 2. Department of Clinical Epidemiology, Aarhus University Hospital, Denmark. 3. Department of Clinical Epidemiology, Aarhus University Hospital, Denmark; Department of Epidemiology, Rollins School of Public Health, Emory University, USA. 4. Department of Cardiothoracic Surgery, Aarhus University Hospital, Denmark. 5. Department of Clinical Genetics, Aarhus University Hospital, Denmark.
Abstract
BACKGROUND: The risk of colorectal cancer (CRC) is reportedly increased two-fold if at least one first-degree relative (FDR) is affected with CRC, increasing to three- to four-fold if multiple FDRs are affected or if one FDR was diagnosed at a young age. We evaluated familial risk of CRC, systematically excluding monogenetic high-risk families with polyposis or Lynch syndrome/hereditary non-polyposis colorectal cancer (HNPCC). METHODS: FDRs of 1196 Danish CRC patients diagnosed between 1995 and 1998 (baseline) were identified and the family history of cancer was assessed at baseline using Danish medical registries; 4182 FDRs without CRC from 1060 of the families were matched on age and gender with ten individuals from the general population and followed from baseline to 2010. Family history was updated with any new cancer event during follow-up. RESULTS: Using Cox proportional hazard modeling the risk estimates were: at least one relative with CRC: hazard ratio (HR)=1.78 (95%CI: 1.45, 2.17), one relative with CRC diagnosed after the age of 50: HR=1.68 (95%CI: 1.32, 2.14), one relative with CRC diagnosed before the age of 50: HR=1.86 (95%CI: 0.70, 4.94), and multiple affected relatives: HR=2.04 (95%CI: 1.38, 3.00). CONCLUSION: Although the overall risk in FDRs of CRC patients in our study was comparable with the results of previous studies, the risk in families with multiple relatives with CRC or one CRC patient diagnosed young may be lower than reported previously.
BACKGROUND: The risk of colorectal cancer (CRC) is reportedly increased two-fold if at least one first-degree relative (FDR) is affected with CRC, increasing to three- to four-fold if multiple FDRs are affected or if one FDR was diagnosed at a young age. We evaluated familial risk of CRC, systematically excluding monogenetic high-risk families with polyposis or Lynch syndrome/hereditary non-polyposis colorectal cancer (HNPCC). METHODS: FDRs of 1196 Danish CRC patients diagnosed between 1995 and 1998 (baseline) were identified and the family history of cancer was assessed at baseline using Danish medical registries; 4182 FDRs without CRC from 1060 of the families were matched on age and gender with ten individuals from the general population and followed from baseline to 2010. Family history was updated with any new cancer event during follow-up. RESULTS: Using Cox proportional hazard modeling the risk estimates were: at least one relative with CRC: hazard ratio (HR)=1.78 (95%CI: 1.45, 2.17), one relative with CRC diagnosed after the age of 50: HR=1.68 (95%CI: 1.32, 2.14), one relative with CRC diagnosed before the age of 50: HR=1.86 (95%CI: 0.70, 4.94), and multiple affected relatives: HR=2.04 (95%CI: 1.38, 3.00). CONCLUSION: Although the overall risk in FDRs of CRC patients in our study was comparable with the results of previous studies, the risk in families with multiple relatives with CRC or one CRC patient diagnosed young may be lower than reported previously.
Authors: Rahma Elmahdi; Elna C M Wennerström; Mikael Andersson; Jan Wohlfahrt; Mads Melbye; Eero Pukkala; Maria Hortlund; Kaisa Silander; Kyösti Sutinen; Tine Jess; Joakim Dillner Journal: Int J Cancer Date: 2022-06-22 Impact factor: 7.316
Authors: Rasa Ruseckaite; Kerri Beckmann; Michael O'Callaghan; David Roder; Kim Moretti; John Zalcberg; Jeremy Millar; Sue Evans Journal: BMC Res Notes Date: 2016-01-22