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Literature DB >> 26223550

Multiplexed TEM Specimen Preparation and Analysis of Plasmonic Nanoparticles.

Sean K Mulligan¹, Jeffrey A Speir¹, Ivan Razinkov^1,2, Anchi Cheng^1,2, John Crum¹, Tilak Jain¹, Erika Duggan³, Er Liu⁴, John P Nolan³, Bridget Carragher^1,2, Clinton S Potter^1,2.

Abstract

We describe a system for rapidly screening hundreds of nanoparticle samples using transmission electron microscopy (TEM). The system uses a liquid handling robot to place up to 96 individual samples onto a single standard TEM grid at separate locations. The grid is then transferred into the TEM and automated software is used to acquire multiscale images of each sample. The images are then analyzed to extract metrics on the size, shape, and morphology of the nanoparticles. The system has been used to characterize plasmonically active nanomaterials.

Entities: Chemical Disease Gene

Keywords: TEM; automation; nanoparticles

Mesh：

Year: 2015 PMID： 26223550 PMCID： PMC4701052 DOI： 10.1017/S1431927615014324

Source DB: PubMed Journal: Microsc Microanal ISSN： 1431-9276 Impact factor: 4.127

22 in total

1. Robotic grid loading system for a transmission electron microscope.

Authors: Clinton S Potter; James Pulokas; Paul Smith; Christian Suloway; Bridget Carragher
Journal: J Struct Biol Date: 2004-06 Impact factor: 2.867

2. Synthesis and optical properties of small Au nanorods using a seedless growth technique.

Authors: Moustafa R K Ali; Brian Snyder; Mostafa A El-Sayed
Journal: Langmuir Date: 2012-06-11 Impact factor: 3.882

3. Automated screening of 2D crystallization trials using transmission electron microscopy: a high-throughput tool-chain for sample preparation and microscopic analysis.

Authors: Nicolas Coudray; Gilles Hermann; Daniel Caujolle-Bert; Argyro Karathanou; Françoise Erne-Brand; Jean-Luc Buessler; Pamela Daum; Juergen M Plitzko; Mohamed Chami; Urs Mueller; Hubert Kihl; Jean-Philippe Urban; Andreas Engel; Hervé-W Rémigy
Journal: J Struct Biol Date: 2010-09-22 Impact factor: 2.867

3. AutoDetect-mNP: An Unsupervised Machine Learning Algorithm for Automated Analysis of Transmission Electron Microscope Images of Metal Nanoparticles.

Authors: Xingzhi Wang; Jie Li; Hyun Dong Ha; Jakob C Dahl; Justin C Ondry; Ivan Moreno-Hernandez; Teresa Head-Gordon; A Paul Alivisatos
Journal: JACS Au Date: 2021-02-25

3 in total

Multiplexed TEM Specimen Preparation and Analysis of Plasmonic Nanoparticles.

1. Robotic grid loading system for a transmission electron microscope.

2. Synthesis and optical properties of small Au nanorods using a seedless growth technique.

3. Automated screening of 2D crystallization trials using transmission electron microscopy: a high-throughput tool-chain for sample preparation and microscopic analysis.

4. Charge- and size-based separation of macromolecules using ultrathin silicon membranes.

5. Towards automated screening of two-dimensional crystals.

6. The ArrayGrid: a methodology for applying multiple samples to a single TEM specimen grid.

7. Suppression of the coffee-ring effect by shape-dependent capillary interactions.

8. Fabrication of metal nanoparticles in metal-organic frameworks.

9. Spotiton: a prototype for an integrated inkjet dispense and vitrification system for cryo-TEM.

10. Iodide in CTAB prevents gold nanorod formation.

Review 1. Automated data collection in single particle electron microscopy.

Review 2. Challenges and opportunities in cryo-EM single-particle analysis.

3. AutoDetect-mNP: An Unsupervised Machine Learning Algorithm for Automated Analysis of Transmission Electron Microscope Images of Metal Nanoparticles.