Valerie Jenkins1, Lesley Fallowfield, Carolyn Langridge, Jessica Barrett, Andy Ryan, Ian Jacobs, Justine Kilkerr, Usha Menon, Vernon Farewell. 1. *Sussex Health Outcomes Research & Education in Cancer (SHORE-C), University of Sussex, Brighton, East Sussex, UK; †Public Health and Primary Care, University of Cambridge, Cambridge, UK; ‡Women's Cancer, Institute for Women's Health, University College London, London, UK; §Chancellery Building, UNSW, Sydney NSW, Australia; and ∥MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK.
Abstract
OBJECTIVE: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to establish the efficacy of 2 different ovarian cancer screening schedules. The psychosocial substudy examines the psychological factors associated with the screening program. METHODS: Women aged 50 to 75 years from 16 UK gynecologic centers randomized to annual multimodal screening or ultrasound screening (US) groups were followed up for 7 years. Psychosocial data from women who withdrew from the study after a repeat screen were examined. RESULTS: Sixteen percent (3499/21,733) of women requiring a repeat screening test in addition to annual screen withdrew from the study: 12.9% (1560/12,073) from the multimodal group and 20.1% (1939/9660) from the US group. An estimated relative risk of withdrawal is 1.46 (95% confidence interval, 1.36-1.56; P ≤ 0.001) for the US arm. High anxiety trait and increased psychological morbidity significantly influenced withdrawal, even when age, screening center, and group were taken into account (P < 0.001). The risk of withdrawal decreased significantly the longer a woman stayed in UKCTOCS, irrespective of the number of screens and intensity in the preceding year. CONCLUSIONS: Withdrawal rate was greater in women undergoing US screening and in those who had repeats earlier in UKCTOCS. Having a high predisposition to anxiety, high current state anxiety, and above threshold general psychological morbidity all increased the withdrawal rate.
OBJECTIVE: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to establish the efficacy of 2 different ovarian cancer screening schedules. The psychosocial substudy examines the psychological factors associated with the screening program. METHODS: Women aged 50 to 75 years from 16 UK gynecologic centers randomized to annual multimodal screening or ultrasound screening (US) groups were followed up for 7 years. Psychosocial data from women who withdrew from the study after a repeat screen were examined. RESULTS: Sixteen percent (3499/21,733) of women requiring a repeat screening test in addition to annual screen withdrew from the study: 12.9% (1560/12,073) from the multimodal group and 20.1% (1939/9660) from the US group. An estimated relative risk of withdrawal is 1.46 (95% confidence interval, 1.36-1.56; P ≤ 0.001) for the US arm. High anxiety trait and increased psychological morbidity significantly influenced withdrawal, even when age, screening center, and group were taken into account (P < 0.001). The risk of withdrawal decreased significantly the longer a woman stayed in UKCTOCS, irrespective of the number of screens and intensity in the preceding year. CONCLUSIONS: Withdrawal rate was greater in women undergoing US screening and in those who had repeats earlier in UKCTOCS. Having a high predisposition to anxiety, high current state anxiety, and above threshold general psychological morbidity all increased the withdrawal rate.
Authors: Elisabeth G Klompenhouwer; Lucien E M Duijm; Adri C Voogd; Gerard J den Heeten; Luc J Strobbe; Marieke W Louwman; Jan Willem Coebergh; Dick Venderink; Mireille J M Broeders Journal: Breast Cancer Res Treat Date: 2014-04-19 Impact factor: 4.872
Authors: Usha Menon; Aleksandra Gentry-Maharaj; Rachel Hallett; Andy Ryan; Matthew Burnell; Aarti Sharma; Sara Lewis; Susan Davies; Susan Philpott; Alberto Lopes; Keith Godfrey; David Oram; Jonathan Herod; Karin Williamson; Mourad W Seif; Ian Scott; Tim Mould; Robert Woolas; John Murdoch; Stephen Dobbs; Nazar N Amso; Simon Leeson; Derek Cruickshank; Alistair McGuire; Stuart Campbell; Lesley Fallowfield; Naveena Singh; Anne Dawnay; Steven J Skates; Mahesh Parmar; Ian Jacobs Journal: Lancet Oncol Date: 2009-03-11 Impact factor: 41.316
Authors: A Gentry-Maharaj; A Sharma; M Burnell; A Ryan; N N Amso; M W Seif; G Turner; C Brunell; G Fletcher; R Rangar; L Fallowfield; S Campbell; I Jacobs; U Menon Journal: Ultrasound Obstet Gynecol Date: 2012-12-11 Impact factor: 7.299
Authors: J Barrett; V Jenkins; V Farewell; U Menon; I Jacobs; J Kilkerr; A Ryan; C Langridge; L Fallowfield Journal: BJOG Date: 2014-05-28 Impact factor: 6.531
Authors: Usha Menon; Aleksandra Gentry-Maharaj; Andy Ryan; Aarti Sharma; Matthew Burnell; Rachel Hallett; Sara Lewis; Alberto Lopez; Keith Godfrey; David Oram; Jonathan Herod; Karin Williamson; Mourad Seif; Ian Scott; Tim Mould; Robert Woolas; John Murdoch; Stephen Dobbs; Nazar Amso; Simon Leeson; Derek Cruickshank; Ali McGuire; Stuart Campbell; Lesley Fallowfield; Steve Skates; Mahesh Parmar; Ian Jacobs Journal: BMJ Date: 2008-11-13
Authors: Helena Harder; Rachel M L Starkings; Lesley J Fallowfield; Usha Menon; Ian J Jacobs; Valerie A Jenkins Journal: Menopause Date: 2019-10 Impact factor: 2.953