Qing Li1, Jian-Hua Zhao1, Peng-Ju Ma2, Lin-Lin Su1, Sheng-Bo Tao1, Si-Bei Ji1. 1. Department of Neurology, First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, P. R. China. 2. Department of Neurosurgery, First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, P. R. China.
Abstract
OBJECTIVE: The present study aims to investigate the relationship between CYP2J2 gene polymorphisms and ischemic stroke (IS) in a Chinese Han population. METHODS: We performed a case-control study including 300 stroke patients and 300 healthy control subjects to compare the distribution of genetic polymorphism G-50T in CYP2J2 gene. RESULTS: We found GT genotype of G-50T in CYP2J2 gene was associated with the risk for IS (13.7% vs. 7.7%, P = 0.037). After adjustment of confounders, the difference remains significant (OR = 1.890, 95% CI: 1.042-3.011). CONCLUSION: CYP2J2 gene polymorphism might increase the risk of stroke in Chinese population.
OBJECTIVE: The present study aims to investigate the relationship between CYP2J2 gene polymorphisms and ischemic stroke (IS) in a Chinese Han population. METHODS: We performed a case-control study including 300 strokepatients and 300 healthy control subjects to compare the distribution of genetic polymorphism G-50T in CYP2J2 gene. RESULTS: We found GT genotype of G-50T in CYP2J2 gene was associated with the risk for IS (13.7% vs. 7.7%, P = 0.037). After adjustment of confounders, the difference remains significant (OR = 1.890, 95% CI: 1.042-3.011). CONCLUSION:CYP2J2 gene polymorphism might increase the risk of stroke in Chinese population.
Entities:
Keywords:
CYP2J2 gene; Ischemic stroke; single nucleotide polymorphism
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