Jiafeng Wang1, Jialei Gu2, Qianbo Han2, Wendong Wang1, Jinbiao Shang2. 1. Department of Head and Neck Surgery, Zhejiang Cancer Hospital Hangzhou, Zhejiang Province, China. 2. Department of Head and Neck Surgery, Zhejiang Cancer Hospital Hangzhou, Zhejiang Province, China ; Wenzhou Medical University Wenzhou, Zhejiang Province, China.
Abstract
BACKGROUND: To assess the diagnostic value of decreased parathyroid hormone (PTH) in hypoparathyroidism after unilateral operation. METHODS: A study was conducted on patients with PTC undergoing total or near-total thyroidectomy plus central neck dissection (CND). RESULTS: Postoperative hypocalcemia was found in 42 patients (51.2%). For patients undergoing bilateral CND, those whose tumor invasion proceeded beyond the thyroid capsule have a higher rate of postoperative hypoparathyroidism (P<0.05). PTH level of hypoparathyroidism patients was lower than that of non-hypoparathyroidism patients from surgery to 6 months later (P<0.05). When unilateral thyroidectomy and central region dissection were completed, PTH level decreased by 47.06% in hypoparathyroidism patients, which was significantly higher than non-hypoparathyroidism patients (28.35%) (P<0.001). PTH level (AUC 0.806) and its decreasing degree (AUC 0.736) played predicting roles in assessing postoperative hypoparathyroidism (P<0.001). CONCLUSIONS: For PTC surgery, PTH level and its decreasing degree played predicting roles in assessing postoperative hypoparathyroidism.
BACKGROUND: To assess the diagnostic value of decreased parathyroid hormone (PTH) in hypoparathyroidism after unilateral operation. METHODS: A study was conducted on patients with PTC undergoing total or near-total thyroidectomy plus central neck dissection (CND). RESULTS:Postoperative hypocalcemia was found in 42 patients (51.2%). For patients undergoing bilateral CND, those whose tumor invasion proceeded beyond the thyroid capsule have a higher rate of postoperative hypoparathyroidism (P<0.05). PTH level of hypoparathyroidismpatients was lower than that of non-hypoparathyroidismpatients from surgery to 6 months later (P<0.05). When unilateral thyroidectomy and central region dissection were completed, PTH level decreased by 47.06% in hypoparathyroidismpatients, which was significantly higher than non-hypoparathyroidismpatients (28.35%) (P<0.001). PTH level (AUC 0.806) and its decreasing degree (AUC 0.736) played predicting roles in assessing postoperative hypoparathyroidism (P<0.001). CONCLUSIONS: For PTC surgery, PTH level and its decreasing degree played predicting roles in assessing postoperative hypoparathyroidism.
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