Shupeng Zhao1, Min Yi2, Yangyang Yuan2, Wenxin Zhuang2, Dengcheng Zhang2, Xiuyi Yu3, Xiaoxuan Chen2, Bogang Teng2, Zhiyu Guan4, Yongxing Zhang2. 1. Department of Thyroid, Breast and Vascular Surgery, The First Affiliated Hospital of Liaoning Medical University Jinzhou 121001, Liaoning, PR China. 2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China. 3. The First Affiliated Hospital of Xiamen University Xiamen 361102, Fujian, PR China. 4. Department of Cardiovascular and Thoracic Surgery, Tianjin Medical University General Hospital 154 Anshan Road, Heping Section, Tianjin 300052, PR China.
Abstract
OBJECTIVE: To investigate correlations among A-kinase anchor protein95 (AKAP95), Connexin43 (Cx43), CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues, and their relationship with clinical and pathological parameters. METHODS: The protein levels of AKAP95, Cx43, CyclinE1 and CyclinD1 in 54 cases of esophageal squamous cell cancer tissues were determined by immunohistochemistry. RESULTS: The expression of AKAP95, CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues (53.70%, 88.89%, 72.22%, respectively) was significantly increased when compared to pericarcinoma tissues (20.00%, P < 0.05; 6.67%, P < 0.01; and 20.00%, P < 0.05; respectively). By contrast, Cx43 expression in esophageal squamous cell cancer tissues (22.22%) was lower than that in pericarcinoma tissues (60.00%, P < 0.05). The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to lymph node metastasis and the degree of differentiation. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was significantly correlated with AKAP95, respectively (P < 0.05). CONCLUSION: Expression levels of AKAP95, CyclinE1 and CyclinD1 were higher, and that of Cx43 lower in esophageal squamous cell carcinoma tissues as compared pericarcinoma tissues, which suggests their importance in the incidence and development of esophageal squamous cell carcinoma. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was correlated with AKAP95, respectively. The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to the degree of differentiation and lymph node metastasis.
OBJECTIVE: To investigate correlations among A-kinase anchor protein95 (AKAP95), Connexin43 (Cx43), CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues, and their relationship with clinical and pathological parameters. METHODS: The protein levels of AKAP95, Cx43, CyclinE1 and CyclinD1 in 54 cases of esophageal squamous cell cancer tissues were determined by immunohistochemistry. RESULTS: The expression of AKAP95, CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues (53.70%, 88.89%, 72.22%, respectively) was significantly increased when compared to pericarcinoma tissues (20.00%, P < 0.05; 6.67%, P < 0.01; and 20.00%, P < 0.05; respectively). By contrast, Cx43 expression in esophageal squamous cell cancer tissues (22.22%) was lower than that in pericarcinoma tissues (60.00%, P < 0.05). The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to lymph node metastasis and the degree of differentiation. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was significantly correlated with AKAP95, respectively (P < 0.05). CONCLUSION: Expression levels of AKAP95, CyclinE1 and CyclinD1 were higher, and that of Cx43 lower in esophageal squamous cell carcinoma tissues as compared pericarcinoma tissues, which suggests their importance in the incidence and development of esophageal squamous cell carcinoma. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was correlated with AKAP95, respectively. The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to the degree of differentiation and lymph node metastasis.
Authors: Solveig Sirnes; Jarle Bruun; Matthias Kolberg; Ane Kjenseth; Guro E Lind; Aud Svindland; Andreas Brech; Arild Nesbakken; Ragnhild A Lothe; Edward Leithe; Edgar Rivedal Journal: Int J Cancer Date: 2011-10-20 Impact factor: 7.396
Authors: Estelle A Wall; Joelle R Zavzavadjian; Mi Sook Chang; Baljinder Randhawa; Xiaocui Zhu; Robert C Hsueh; Jamie Liu; Adrienne Driver; Xiaoyan Robert Bao; Paul C Sternweis; Melvin I Simon; Iain D C Fraser Journal: Sci Signal Date: 2009-06-16 Impact factor: 8.192
Authors: Martin Lodén; Maria Stighall; Niels Hilmer Nielsen; Göran Roos; Stefan O Emdin; Hanna Ostlund; Göran Landberg Journal: Oncogene Date: 2002-07-11 Impact factor: 9.867