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Literature DB >> 30982750

AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.

Terri Clister¹, Eric C Greenwald², George S Baillie³, Jin Zhang⁴.

Abstract

Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear PKA.

Entities: CellLine Chemical Disease Gene Species

Keywords: FRET biosensors; compartmentalization; imaging; spatiotemporal

Mesh：

Substances：

Year: 2019 PMID： 30982750 PMCID： PMC6588460 DOI： 10.1016/j.chembiol.2019.03.003

Source DB: PubMed Journal: Cell Chem Biol ISSN： 2451-9448 Impact factor: 8.116

25 in total

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4. Characterization of the FKBP.rapamycin.FRB ternary complex.

Authors: Laura A Banaszynski; Corey W Liu; Thomas J Wandless
Journal: J Am Chem Soc Date: 2005-04-06 Impact factor: 15.419

5. G1/S Cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95.

Authors: Tatjana Arsenijevic; Chantal Degraef; Jacques E Dumont; Pierre P Roger; Isabelle Pirson
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6. A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines.

Authors: Angela L Asirvatham; Sarah G Galligan; Robynn V Schillace; Michael P Davey; Valeria Vasta; Joseph A Beavo; Daniel W Carr
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7. Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication.

Authors: Turid Eide; Kristin A Taskén; Cathrine Carlson; Gareth Williams; Tore Jahnsen; Kjetil Taskén; Philippe Collas
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8. A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.

Authors: Tatjana Arsenijevic; Chantal Degraef; Jacques E Dumont; Pierre P Roger; Isabelle Pirson
Journal: Biochem J Date: 2004-03-01 Impact factor: 3.857

9. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis.

Authors: P Collas; K Le Guellec; K Taskén
Journal: J Cell Biol Date: 1999-12-13 Impact factor: 10.539

10. PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

Authors: Anna Terrin; Giulietta Di Benedetto; Vanessa Pertegato; York-Fong Cheung; George Baillie; Martin J Lynch; Nicola Elvassore; Anke Prinz; Friedrich W Herberg; Miles D Houslay; Manuela Zaccolo
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13 in total

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Review 2. AKAP Signaling Islands: Venues for Precision Pharmacology.

Authors: Mitchell H Omar; John D Scott
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Review 3. Milestones in the development and implementation of FRET-based sensors of intracellular signals: A biological perspective of the history of FRET.

Authors: J Deal; D J Pleshinger; S C Johnson; S J Leavesley; T C Rich
Journal: Cell Signal Date: 2020-09-06 Impact factor: 4.315

4. Norepinephrine activates β₁ -adrenergic receptors at the inner nuclear membrane in astrocytes.

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Journal: Glia Date: 2022-05-19 Impact factor: 8.073