| Literature DB >> 26218790 |
Zihua Wang, Weizhi Wang, Xiangli Bu, Zewen Wei, Lingling Geng, Yue Wu1, Chengyan Dong1, Liqiang Li1, Di Zhang, Shu Yang, Fan Wang1, Christopher Lausted2, Leroy Hood2, Zhiyuan Hu2,3.
Abstract
Peptides are excellent biointerface molecules and diagnostic probes with many advantages such as good penetration, short turnover time, and low cost. We report here an efficient peptide screening strategy based on in situ single bead sequencing on a microarray. Two novel peptides YLFFVFER (H6) and KLRLEWNR (H10) specifically binding to the tumor biomarker human epidermal growth factor receptor 2 (HER2) with aKD of 10(-8) M were obtained from a 10(5) library. Conjugated to nanoparticles, both the H6 and H10 probes showed specific accumulation in HER2-positive tumor tissues in xenografted mice by in vivo imaging.Entities:
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Year: 2015 PMID： 26218790 DOI： 10.1021/acs.analchem.5b01588
Source DB: PubMed Journal: Anal Chem ISSN： 0003-2700 Impact factor: 6.986