Timothy B Niewold1. 1. Division of Rheumatology, Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Abstract
PURPOSE OF REVIEW: The field of systemic lupus erythematosus (SLE) genetics has been advancing rapidly in recent years. This review will summarize recent advances in SLE genetics. RECENT FINDINGS: Genome-wide-association and follow-up studies have greatly expanded the list of associated polymorphisms, and much current work strives to integrate these polymorphisms into immune system biology and the pathogenic mediators involved in the disease. This review covers some current areas of interest, including genetic studies in non-European SLE patient populations, studies of pathogenic immune system subphenotypes such as type I interferon and autoantibodies, and a rapidly growing body of work investigating the functional consequences of the genetic polymorphisms associated with SLE. SUMMARY: These studies provide a fascinating window into human SLE disease biology. As the work proceeds from genetic association signal to altered human biology, we move closer to tailoring interventions based upon an individual's genetic substrate.
PURPOSE OF REVIEW: The field of systemic lupus erythematosus (SLE) genetics has been advancing rapidly in recent years. This review will summarize recent advances in SLE genetics. RECENT FINDINGS: Genome-wide-association and follow-up studies have greatly expanded the list of associated polymorphisms, and much current work strives to integrate these polymorphisms into immune system biology and the pathogenic mediators involved in the disease. This review covers some current areas of interest, including genetic studies in non-European SLEpatient populations, studies of pathogenic immune system subphenotypes such as type I interferon and autoantibodies, and a rapidly growing body of work investigating the functional consequences of the genetic polymorphisms associated with SLE. SUMMARY: These studies provide a fascinating window into humanSLE disease biology. As the work proceeds from genetic association signal to altered human biology, we move closer to tailoring interventions based upon an individual's genetic substrate.
Authors: Kichul Ko; Beverly S Franek; Miranda Marion; Kenneth M Kaufman; Carl D Langefeld; John B Harley; Timothy B Niewold Journal: J Rheumatol Date: 2012-04-15 Impact factor: 4.666
Authors: Corinna E Weckerle; Beverly S Franek; Jennifer A Kelly; Marissa Kumabe; Rachel A Mikolaitis; Stephanie L Green; Tammy O Utset; Meenakshi Jolly; Judith A James; John B Harley; Timothy B Niewold Journal: Arthritis Rheum Date: 2011-04
Authors: Stephen J Chapman; Chiea C Khor; Fredrik O Vannberg; Nicholas A Maskell; Christopher W H Davies; Emma L Hedley; Shelley Segal; Catrin E Moore; Kyle Knox; Nicholas P Day; Stephen H Gillespie; Derrick W Crook; Robert J O Davies; Adrian V S Hill Journal: Nat Genet Date: 2006-05 Impact factor: 38.330
Authors: Christian J Maine; Emma E Hamilton-Williams; Jocelyn Cheung; Stephanie M Stanford; Nunzio Bottini; Linda S Wicker; Linda A Sherman Journal: J Immunol Date: 2012-04-25 Impact factor: 5.422
Authors: Robert R Graham; Sergey V Kozyrev; Emily C Baechler; M V Prasad Linga Reddy; Robert M Plenge; Jason W Bauer; Ward A Ortmann; Thearith Koeuth; Ma Francisca González Escribano; Bernardo Pons-Estel; Michelle Petri; Mark Daly; Peter K Gregersen; Javier Martín; David Altshuler; Timothy W Behrens; Marta E Alarcón-Riquelme Journal: Nat Genet Date: 2006-04-16 Impact factor: 38.330
Authors: Silvia N Kariuki; Kyriakos A Kirou; Emma J MacDermott; Lilliana Barillas-Arias; Mary K Crow; Timothy B Niewold Journal: J Immunol Date: 2009-01-01 Impact factor: 5.422
Authors: J Nititham; K E Taylor; R Gupta; H Chen; R Ahn; J Liu; M Seielstad; A Ma; A M Bowcock; L A Criswell; M Stahle; W Liao Journal: Genes Immun Date: 2014-12-18 Impact factor: 2.676
Authors: Christopher M Tipton; Jennifer R Hom; Christopher F Fucile; Alexander F Rosenberg; Inaki Sanz Journal: Immunol Rev Date: 2018-07 Impact factor: 12.988
Authors: K A Young; M E Munroe; J M Guthridge; D L Kamen; G S Gilkensen; J B Harley; M H Weisman; D R Karp; D J Wallace; J A James; J M Norris Journal: Lupus Date: 2019-03-07 Impact factor: 2.911
Authors: Rufei Lu; Melissa E Munroe; Joel M Guthridge; Krista M Bean; Dustin A Fife; Hua Chen; Samantha R Slight-Webb; Michael P Keith; John B Harley; Judith A James Journal: J Autoimmun Date: 2016-06-20 Impact factor: 7.094