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Literature DB >> 26214499

A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity.

Chang Yeol Lee¹, Ki Soo Park, Hyun Gyu Park.

Abstract

A sensitive and selective assay of uracil DNA glycosylase (UDG) activity is developed by utilizing a G-quadruplex probe incorporating 2-aminopurine (2-AP), based on a novel design that excision reaction promoted by UDG triggers the formation of G-quadruplex structure with significant fluorescence enhancement of 2-AP within the probe.

Entities: Chemical Gene

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Year: 2015 PMID： 26214499 DOI： 10.1039/c5cc05010c

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

7 in total

Review 1. In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

Authors: Janos Sagi
Journal: J Nucleic Acids Date: 2017-10-18

2. Electrochemiluminescent determination of the activity of uracil-DNA glycosylase: Combining nicking enzyme assisted signal amplification and catalyzed hairpin assembly.

Authors: Qiao Liu; Chao Liu; Guang Zhu; Haifeng Xu; Xiao Jie Zhang; Chongju Hu; Yong Xie; Keying Zhang; Hongyan Wang
Journal: Mikrochim Acta Date: 2019-02-15 Impact factor: 5.833

Review 3. Fluorescent Probes of DNA Repair.

Authors: David L Wilson; Eric T Kool
Journal: ACS Chem Biol Date: 2017-11-30 Impact factor: 5.100

A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity.

Review 1. In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

2. Electrochemiluminescent determination of the activity of uracil-DNA glycosylase: Combining nicking enzyme assisted signal amplification and catalyzed hairpin assembly.

Review 3. Fluorescent Probes of DNA Repair.

4. Universally applicable, quantitative PCR method utilizing fluorescent nucleobase analogs.

5. Protein-induced fluorescence enhancement for a simple and universal detection of protein/small molecule interactions.

6. Stable Domain Assembly of a Monomolecular DNA Quadruplex: Implications for DNA-Based Nanoswitches.

Review 7. C-Linked 8-aryl guanine nucleobase adducts: biological outcomes and utility as fluorescent probes.